| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
we made spinal cord contusion model mice(C57BL/6 mouse (wild type), plt mouse (CCL21kock-out)) at T9 level . I performed a sharp pain-related evaluation and immunohistochemistry of the microglia/macrophage,the change of M1/M2 polarity as of 4, 14, 28th. The plt mouse accepted a drop of the sharp pain threshold by the sharp pain-related evaluation in comparison with wild type. The result that M1 decreased was provided with the plt mouse by the immunohistochemical evaluation in comparison with wild type. This result suggested that influence left for a drop of the sharp pain threshold and polar change of M1M2 by the loss of CCL21.
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