The development of innovative therapy for intervertebral disc degeneration targeted to the RANK/RANKL/OPG system
| Project/Area Number |
26861184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
Takegami Norihiko 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (20727664)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 椎間板変性 / RANKL / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
The present study showed that the expression of RANK/RANKL/OPG system was confirmed both by mRNA and protein levels in the rat and human intervertebral discs.
The expressions of RANK/RANKL/OPG were regulated by stimulation with IL-1β. Those of proinflammatory cytokines and proteolytic enzymes were significantly up-regulated by stimulation with RANKL in the presence of IL-1β stimulation.
The RANK/RANKL/OPG system has the potential to interact with proinflammatory cytokines and be involved in the progression of disc degeneration.
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Report
(3 results)
Research Products
(11 results)
