Establishment of percutaneous carbon dioxide therapy for acceleration of the fracture repair

• Project/Area Number: 26861190
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: Iwakura Takashi 神戸大学, 医学部附属病院, 医員 (60437473)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 炭酸ガス / 骨折治癒促進 / 大腿骨閉鎖性骨折 / 骨癒合 / 軟骨内骨化

Outline of Final Research Achievements

We investigated the optimal duration and interval of percutaneous carbon dioxide (CO2) therapy for fracture repair by using rat closed femoral fracture model. The present study demonstrated that continuous CO2 therapy throughout the process of fracture repair was effective in the enhancement of fracture repair. Although CO2 therapy twice a week was also effective for fracture repair, continuous CO2 therapy was more effective for fracture repair. The results of this investigation would provide useful information on the application of this system in the clinical setting.

Research Products

• [Presentation] 炭酸ガスを利用した新しい偽関節治療 (2015)
  • Author(s): 新倉隆宏、李相亮、岩倉崇、黒坂昌弘
  • Organizer: 第124回中部日本整形外科災害外科学会・学術集会
  • Place of Presentation: 金沢（石川県）
  • Year and Date: 2015-04-10
• [Presentation] The Effects of the Duration of Transcutaneous CO2 Application on the Facilitatory Effect in Rat Fracture Repair (2015)
  • Author(s): Takashi Iwakura, Takahiro Niikura, Sang Yang Lee, Etsuko Okumachi, Takahiro Waki, Syunsuke Takahara, Michio Arakura, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka
  • Organizer: The 61th Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: Las Vegas (USA)
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] 炭酸ガス経皮吸収の継続期間が骨折治癒に与える影響 (2015)
  • Author(s): 岩倉崇、新倉隆宏、李相亮、黒田良祐、黒坂昌弘
  • Organizer: 第28回日本創外固定・骨延長学会
  • Place of Presentation: 六本木ヒルズ（東京都）
  • Year and Date: 2015-03-20 – 2015-03-21
• [Presentation] 炭酸ガス経皮吸収の期間が骨折治癒促進作用に与える影響の検討 (2014)
  • Author(s): 岩倉崇、新倉隆宏、李相亮、堂垣佳宏、奥町悦子、脇貴洋、高原俊介、黒坂昌弘
  • Organizer: 第40回日本骨折治療学会
  • Place of Presentation: 熊本市（熊本県）
  • Year and Date: 2014-06-27 – 2014-06-28