Transcutaneous Carbon Dioxide Application With Hydrogel Prevents Muscle Atrophy in a Rat Sciatic Nerve Crush Model
| Project/Area Number |
26861194
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-03-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 炭酸ガス経皮吸収 / 末梢神経損傷 / 人工ボーア効果 / 筋萎縮 / 神経損傷 / 炭酸ガス / 経皮吸収 / 経皮投与 |
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| Outline of Final Research Achievements |
The acceleration of nerve regeneration remains a clinical challenge. We previously demonstrated that transcutaneous CO2 application using a novel hydrogel increases the oxygen concentration in local tissue via an “artificial Bohr effect” with the potential to prevent muscle atrophy. In this study, we investigated the effect of transcutaneous CO2 administration on limb function after peripheral nerve injury in a rat sciatic nerve injury model. Rats were divided into a sham group, a control group or a CO2 group. CO2 was administered percutaneously for 20 min five times per week. In this study, good results were obtained in the CO2 group compared with the control group from behavioral evaluation, nerve conduction study, analysis of messenger RNA (mRNA) expression, wet muscle weight and histological analysis.Transcutaneous CO2 application has the therapeutic potential to accelerate the recovery of muscle atrophy in peripheral nerve injury.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Transcutaneous carbon dioxide application with hydrogel prevents muscle atrophy in a rat sciatic nerve crush model.2017
Author(s)
Nishimoto H, Inui A, Ueha T, Inoue M, Akahane S, Harada R, Mifune Y, Kokubu T, Nishida K, Kuroda R, Sakai Y.
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Journal Title
Journal of Orthopaedic Research
Volume: 印刷中
Issue: 6
Pages: 1653-1658
DOI
Related Report
Peer Reviewed / Open Access
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