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Transcutaneous Carbon Dioxide Application With Hydrogel Prevents Muscle Atrophy in a Rat Sciatic Nerve Crush Model

Research Project

Project/Area Number 26861194
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKobe University

Principal Investigator

Nishimoto Hanako  神戸大学, 医学部附属病院, 医員 (30707154)

Project Period (FY) 2015-03-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords炭酸ガス経皮吸収 / 末梢神経損傷 / 人工ボーア効果 / 筋萎縮 / 神経損傷 / 炭酸ガス / 経皮吸収 / 経皮投与
Outline of Final Research Achievements

The acceleration of nerve regeneration remains a clinical challenge. We previously demonstrated that transcutaneous CO2 application using a novel hydrogel increases the oxygen concentration in local tissue via an “artificial Bohr effect” with the potential to prevent muscle atrophy. In this study, we investigated the effect of transcutaneous CO2 administration on limb function after peripheral nerve injury in a rat sciatic nerve injury model. Rats were divided into a sham group, a control group or a CO2 group. CO2 was administered percutaneously for 20 min five times per week. In this study, good results were obtained in the CO2 group compared with the control group from behavioral evaluation, nerve conduction study, analysis of messenger RNA (mRNA) expression, wet muscle weight and histological analysis.Transcutaneous CO2 application has the therapeutic potential to accelerate the recovery of muscle atrophy in peripheral nerve injury.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Transcutaneous carbon dioxide application with hydrogel prevents muscle atrophy in a rat sciatic nerve crush model.2017

    • Author(s)
      Nishimoto H, Inui A, Ueha T, Inoue M, Akahane S, Harada R, Mifune Y, Kokubu T, Nishida K, Kuroda R, Sakai Y.
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 印刷中 Issue: 6 Pages: 1653-1658

    • DOI

      10.1002/jor.23817

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The effect of transcutaneous carbon dioxide (CO2) administration2017

    • Author(s)
      乾 淳幸、西本 華子、美舩 泰、国分 毅、上羽 岳志、黒田 良祐、酒井 良忠
    • Organizer
      The ORS 2017 Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ハイドロゲルを使用した経皮的炭酸ガス投与によるラット末梢神経障害の治療2016

    • Author(s)
      乾 淳幸、国分 毅、美舩 泰、黒坂 昌弘
    • Organizer
      第27回末梢神経学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 神経圧挫モデルでの神経・筋肉機能回復過程における炭酸ガス経皮吸収の効果について2016

    • Author(s)
      西本 華子,乾 淳幸,上羽 岳志,赤羽 志保,高瀬 史明,植田 安洋,国分 毅,黒坂 昌弘,酒井 良忠
    • Organizer
      第53回日本リハビリテーション医学会学術集会
    • Place of Presentation
      国立京都国際会館 グランドプリンスホテル京都
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 炭酸ガス経皮吸収はラット坐骨神経圧挫モデルの運動機能を回復させる2016

    • Author(s)
      乾 淳幸、西本 華子、国分 毅、美舩 泰、高瀬 史明、植田 安洋、片岡 武史、黒坂 昌弘
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜会議センター(神奈川県横浜市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 炭酸ガス経皮吸収はラット坐骨神経圧挫モデルの運動機能を回復させる2016

    • Author(s)
      乾 淳幸,西本 華子,上羽 岳志,赤羽 志保,高瀬 史明,植田 安洋,国分 毅,黒坂 昌弘,酒井 良忠
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 経皮的炭酸ガス投与は末梢神経障害を改善させる2016

    • Author(s)
      乾 淳幸、西本 華子、国分 毅、美舩 泰、高瀬 史明
    • Organizer
      第59回日本手外科学会学術集会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット坐骨神経圧挫モデルに対するハイドロゲルを使用した経皮的炭酸ガス投与2016

    • Author(s)
      乾 淳幸,西本 華子,植田 安洋,美舩 泰,国分 毅
    • Organizer
      第59回日本手外科学会学術集会
    • Place of Presentation
      広島国際 会議場
    • Year and Date
      2016-04-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Transcutaneous application of carbon dioxide (CO2) enhanced limb function in rat sciatic nerve crush model.2016

    • Author(s)
      Nishimoto H, Inui A, Ueha T, Harada R, Akahane S,Inoue M, Kokubu T,Kurosaka M,Sakai Y
    • Organizer
      62th Annual Meeting of Orthopaedic Research Society
    • Place of Presentation
      Florida
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経圧挫モデルでの神経・筋肉機能回復過程における炭酸ガス経皮吸収の効果について2015

    • Author(s)
      西本 華子,乾 淳幸,上羽 岳志,赤羽 志保,高瀬 史明,植田 安洋,国分 毅,黒坂 昌弘,酒井 良忠
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-07-29  

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