Treatment and prevention for fragility fracture using molecular evolution engineering and advanced adhesive technology

• Project/Area Number: 26861195
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Sugimoto Yoshihisa 岡山大学, 大学病院, 助教 (80423309)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生体材料 / 結合性改変成長因子 / コラーゲン結合性ドメイン / BMP

Outline of Final Research Achievements

We have studied about treatment and prevention for fragility fracture using molecular evolution engineering and advanced adhesive technology. CBD-BMP4 showed significantly better fixing stability both in vitro and vivo than BMP4. We assessed bone regeneration using CBD-BMP4 and BMP4 within bone defect of mice and rabbits. CBD-BMP4 showed good bone regeneration. According to real-time PCR, CBD-BMP4 indicated higher expression in ALP and osteocalcin.