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Hyperglycemia during acute spinal cord injury is a preventable risk factor for spinal cord injury - Translational research from animals to humans -

Research Project

Project/Area Number 26861198
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionJapan Organization of Occupational Health and Safety, Spinal Injuries Center (2016)
Kyushu University (2014-2015)

Principal Investigator

Kubota Kensuke  独立行政法人労働者健康安全機構総合せき損センター(研究部), 独立行政法人労働者健康安全機構総合せき損センター(研究部), 研究員(移行) (00717069)

Research Collaborator KOBAYAKAWA KAZU  九州大学, 大学病院, 助教 (40772322)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脊髄損傷 / 高血糖 / 機能予後 / ミクログリア / 神経学的予後
Outline of Final Research Achievements

Under hyperglycemic conditions, both in vivo and in vitro, inflammation was enhanced through promotion of the nuclear translocation of the nuclear factor κB (NF-κB) transcription factor in microglial cells. During acute SCI, hyperglycemic mice exhibited progressive neural damage, with more severe motor deficits than those observed in normoglycemic mice. Consistent with the animal study findings, a Pearson χ2 analysis of data for 528 patients with SCI indicated that hyperglycemia on admission was a significant risk predictor of poor functional outcome. Moreover, a multiple linear regression analysis showed hyperglycemia at admission to be a powerful independent risk factor for a poor motor outcome. Manipulating blood glucose during acute SCI in hyperglycemic mice rescued the exacerbation of pathophysiology and improved motor functional outcomes. These results suggest that glycemic control may be needed to improve recovery after acute spinal cord injury in human patients.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans2014

    • Author(s)
      Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 256 Pages: 256-256

    • DOI

      10.1126/scitranslmed.3009430

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 脊髄損傷後の急性高血糖症はマウスおよび 患者における機能回復を阻害する2016

    • Author(s)
      小早川 和
    • Organizer
      第44回日本救急医学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Acute hyperglycemia is a treatable risk factor for spinal cord injury - translational research from animals to humans -2016

    • Author(s)
      Kazu Kobayakawa
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷発生時のマネージメント2016

    • Author(s)
      久保田 健介
    • Organizer
      第27回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Hyperglycemic over-activation of microglia deteriorates functional outcomes after spinal cord injury -translational research between animals and humans-2016

    • Author(s)
      Kazu Kobayakawa
    • Organizer
      European Congress of Cytology
    • Place of Presentation
      Liverpool, UK
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hyperglycemia impairs functional recovery after spinal cord injury2016

    • Author(s)
      Kensuke Kubota
    • Organizer
      The 55th International Spinal Cord Society Annual Scientific Meeting
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute hyperglycemia is a treatable risk factor for spinal cord injury. Translational research of animals and humans2016

    • Author(s)
      Kazu Kobayakawa
    • Organizer
      European Orthopaedic Research Society 24th Annual Meeting
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hyperglycemia during acute spinal cord injury is a detrimental factor that impairs functional improvement2016

    • Author(s)
      Kensuke Kubota
    • Organizer
      The 17th European Federation of National Associations of Orthopaedics and Traumatology
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2016-06-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hyperglycemia is a Preventable Risk Factor for Spinal Cord Injury – Translational Research from Animals to Humans2016

    • Author(s)
      Kobayakawa K, Okada S, Kubota K, Yokota K, Ohkawa Y, Saito T, Hara M, Kijima K, Ideta R, Shiba K, Iwamoto Y
    • Organizer
      2016 Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性期高血糖は脊髄損傷の運動機能回復を悪化させる2015

    • Author(s)
      小早川和, 岡田誠司, 横田和也, 久保田健介,芝啓一郎, 岩本幸英
    • Organizer
      第50回日本脊髄障害医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Acute hyperglycemia impairs functional recovery after spinal cord injury2015

    • Author(s)
      Kubota K, Kobayakawa K, Okada S, Shiba K, Iwamoto Y
    • Organizer
      The 8th Asian Conference for Emergency Medicine
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷後の急性期高血糖は運動機能回復を有意に阻害する–脊髄損傷急性期の血糖管理-2015

    • Author(s)
      小早川和, 岡田誠司, 久保田健介, 横田和也, 齊藤武恭, 原正光, 芝啓一郎, 岩本幸英
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Hyperglycemia during acute spinal cord injury is a detrimental factor that impairs functional improvement in acute C3/4 cord injury patients without any bony damages.2015

    • Author(s)
      Kubota K, Kobayakawa K, Okada S, Shiba K, Iwamoto Y
    • Organizer
      The 28th Annual Congress of the European Society of Intensive Care Medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acute Hyperglycemia Is A Treatable Risk Factor For Spinal Cord Injury: Animal Experiment And Human Cohort Study2015

    • Author(s)
      Kazu Kobayakawa, Kensuke Kubota, Kazuya Yokota, Seiji Okada, Yukihide Iwamoto
    • Organizer
      Orthopaedic Research Society 2015 Annual Meeting
    • Place of Presentation
      Las vegas, USA
    • Year and Date
      2015-03-28 – 2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 高血糖はミクログリアのNF-κBの過度な活性化を介して脊髄損傷後の二次損傷と機能予後を増悪させる2014

    • Author(s)
      小早川和, 岡田誠司, 久保田健介, 横田和也, 齊藤武恭, 芝啓一郎, 岩本幸英
    • Organizer
      第49回日本脊髄障害医学会
    • Place of Presentation
      旭川
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Acute hyperglycemia exacerbates functional outcomes in human and mouse spinal cord injury via NF-κB pathway.2014

    • Author(s)
      Kobayakawa K, Saiwai H, Kumamaru H, Kubota K, Yokota K, Ohkawa Y, Kishimoto J, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S.
    • Organizer
      EFNS-ENS Joint Congress of European Neurology 2014
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-05-31 – 2014-06-03
    • Related Report
      2014 Research-status Report
  • [Book] 臨床整形外科2015

    • Author(s)
      小早川和, 岡田誠司, 久保田健介, 出田良輔, 芝啓一郎, 岩本幸英
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Remarks] 脊髄損傷急性期の高血糖が運動麻痺の予後を悪化させることを発見 岡田准教授

    • URL

      http://www.med.kyushu-u.ac.jp/app/modules/information/detail.php?i=722&c=10

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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