Hyperglycemia during acute spinal cord injury is a preventable risk factor for spinal cord injury - Translational research from animals to humans -
| Project/Area Number |
26861198
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Japan Organization of Occupational Health and Safety, Spinal Injuries Center (2016)
Kyushu University (2014-2015) |
|---|
Principal Investigator |
Kubota Kensuke 独立行政法人労働者健康安全機構総合せき損センター(研究部), 独立行政法人労働者健康安全機構総合せき損センター(研究部), 研究員(移行) (00717069)
|
|---|
| Research Collaborator |
KOBAYAKAWA KAZU 九州大学, 大学病院, 助教 (40772322)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 脊髄損傷 / 高血糖 / 機能予後 / ミクログリア / 神経学的予後 |
|---|
| Outline of Final Research Achievements |
Under hyperglycemic conditions, both in vivo and in vitro, inflammation was enhanced through promotion of the nuclear translocation of the nuclear factor κB (NF-κB) transcription factor in microglial cells. During acute SCI, hyperglycemic mice exhibited progressive neural damage, with more severe motor deficits than those observed in normoglycemic mice. Consistent with the animal study findings, a Pearson χ2 analysis of data for 528 patients with SCI indicated that hyperglycemia on admission was a significant risk predictor of poor functional outcome. Moreover, a multiple linear regression analysis showed hyperglycemia at admission to be a powerful independent risk factor for a poor motor outcome. Manipulating blood glucose during acute SCI in hyperglycemic mice rescued the exacerbation of pathophysiology and improved motor functional outcomes. These results suggest that glycemic control may be needed to improve recovery after acute spinal cord injury in human patients.
|
Report
(4 results)
Research Products
(18 results)
-
[Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans2014
Author(s)
Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S
-
Journal Title
Science Translational Medicine
Volume: 6
Issue: 256
Pages: 256-256
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
[Presentation] Hyperglycemia is a Preventable Risk Factor for Spinal Cord Injury – Translational Research from Animals to Humans2016
Author(s)
Kobayakawa K, Okada S, Kubota K, Yokota K, Ohkawa Y, Saito T, Hara M, Kijima K, Ideta R, Shiba K, Iwamoto Y
Organizer
2016 Annual Meeting of the Orthopaedic Research Society
Place of Presentation
Orlando, Florida, USA
Year and Date
2016-03-05
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
[Presentation] Acute hyperglycemia exacerbates functional outcomes in human and mouse spinal cord injury via NF-κB pathway.2014
Author(s)
Kobayakawa K, Saiwai H, Kumamaru H, Kubota K, Yokota K, Ohkawa Y, Kishimoto J, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S.
Organizer
EFNS-ENS Joint Congress of European Neurology 2014
Place of Presentation
Istanbul, Turkey
Year and Date
2014-05-31 – 2014-06-03
Related Report
-
[Book] 臨床整形外科2015
Author(s)
小早川和, 岡田誠司, 久保田健介, 出田良輔, 芝啓一郎, 岩本幸英
Total Pages
5
Publisher
医学書院
Related Report
-
