Properties of silver oxide-containing hydroxyapatite coating implant
| Project/Area Number |
26861199
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 銀 / ハイドロキシアパタイト / 感染 / 人工関節 |
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| Outline of Final Research Achievements |
Our preparation of silver oxide-containing hydroxyapatite (Ag-HA) showed the property of both osteoconductivity of HA and antibacterial activity of silver, without any adverse reaction to silver. Furthermore, it was able to prevent biofilm formation, which plays important role in infection, in vitro and in vivo experiments. In the crinical trial of Ag-HA coated implants for total hip arthroplasty, patients had improved their pain, function and activity of daily living without any side effects.
Ag-HA is promising as a means of reducing postoperative infection, preventing decreased quality of life, and obtaining favorable outcomes in patients undergoing prosthetic arthroplasty.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Silver oxide-containing hydroxyapatite coating supports osteoblast function and enhances implant anchorage strength in rat femur.2015
Author(s)
Eto S, Miyamoto H, Shobuike T, Noda I, Akiyama T, Tsukamoto M, Ueno M, Someya S, Kawano S, Sonohata M, Mawatari M.
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Journal Title
Journal of orthopaedic research
Volume: 印刷中
Issue: 9
Pages: 1391-1397
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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