| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Our preparation of silver oxide-containing hydroxyapatite (Ag-HA) showed the property of both osteoconductivity of HA and antibacterial activity of silver, without any adverse reaction to silver. Furthermore, it was able to prevent biofilm formation, which plays important role in infection, in vitro and in vivo experiments. In the crinical trial of Ag-HA coated implants for total hip arthroplasty, patients had improved their pain, function and activity of daily living without any side effects.
Ag-HA is promising as a means of reducing postoperative infection, preventing decreased quality of life, and obtaining favorable outcomes in patients undergoing prosthetic arthroplasty.
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