Risk factors for intervertebral disc degeneration, neck pain, and low back pain in a longitudinal population-based cohort: the Wakayama Spine Study
Project/Area Number |
26861206
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Wakayama Medical University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 椎間板変性 / 腰痛 / 脊椎変性疾患 / 一般住民コホート / 疫学 / High Intensity Zone / 腰痛関連生活障害 / 危険因子 / メタボリックシンドローム / 頸部痛・腰痛 / 椎間板変性の有病率 / 腰痛と椎間板変性の関連 / 椎間板変性の危険因子 / 大規模コホート / MRI |
Outline of Final Research Achievements |
The study established the baseline data of disc degeneration over the entire spine in a large population cohort (Osteoarthritis and Cartilage 2014). Further, the study correlated degenerative changes as observed on MRI with back pain (The Spine Journal 2015). The present longitudinal study is the first to determine the progression, incidence, and risk factors for disc degeneration in the lumbar spine using MRI (PLOS ONE 2016). And we followed up participants 4 years after the baseline study at 2008, achieving a 75.6% participation rate in our follow-up survey. We found high rates of disc degeneration progression and incidence in Japanese elderly people. We elucidated that aging was significantly associated with incidence. Moreover, female was significantly associated with disc degeneration progression in the upper lumbar spine. Furthermore, Diabetes mellitus was significantly associated with disc degeneration incidence in the upper lumbar spine (Osteoarthritis and Cartilage 2017).
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Serum levels of matrix metalloproteinase and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.2018
Author(s)
R Kodama, S Muraki, T Iidaka, H Oka, M Teraguchi, R Kagotani, Y Asai, H Hashizume, M Yoshida, H Kawaguchi, K Nakamura, T Akune, S Tanaka, N Yoshimura
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Journal Title
J Bone Miner Metab
Volume: 36
Pages: 246-253
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort2017
Author(s)
M Teraguchi, N Yoshimura, H hashizume, H Yamada, H Oka, A Minamide, K Nagata, Y Ishimoto, R Kagotani, H Kawaguchi, S Tanaka, T Akune, K Nakamura, S Muraki, M Yoshida
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Journal Title
Osteoarthritis and Cartilage
Volume: 25
Pages: 1122-31
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study.2017
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M.
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Journal Title
Osteoarthritis Cartilage
Volume: 印刷中
Issue: 7
Pages: 1122-1131
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.2016
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
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Journal Title
PLoS One
Volume: 11
Issue: 2
Pages: e0147565-e0147565
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study.2016
Author(s)
Teraguchi M, Samartzis D, Hashizume H, Yamada H, Muraki S, Oka H, Cheung JP, Kagotani R, Iwahashi H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Cheung KM, Yoshimura N, Yoshida M.
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Journal Title
PLoS One
Volume: 11
Issue: 9
Pages: e0160111-e0160111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 3.The association of combination of disc degeneration, end plate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study.2015
Author(s)
M. Teraguchi, N. Yoshimura, H. Hashizume, S. Muraki, H. Yamada, H. Oka, A. Minamide, Y Nakagawa, Y. Ishimoto, K. Nagata, R. Kagotani, N. Tanaka, S. Kawaguchi,K. Nakamura,T.Akune,M. Yoshida
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Journal Title
The Spine journal
Volume: 15
Pages: 622-628
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 1.Metabolic syndrome components are associated with intervertebral disc degeneration: the Wakayama Spine Study2015
Author(s)
M. Teraguchi, N. Yoshimura, H. Hashizume, S. Muraki, H. Yamada, H. Oka, A. Minamide, Y. Ishimoto, K. Nagata, R. Kagotani, N. Tanaka, S. Kawaguchi,K. Nakamura,T.Akune,M. Yoshida
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The association of combination of disc degeneration, endplate signal change, and Schmorl’s node with low back pain in a large population study: the Wakayama Spine Study2015
Author(s)
M Teraguchi, N Yoshimura, H Hashizume, S Muraki, H Yamada, H Oka, A Minamide, H Nakagawa, Y Ishimoto, K Nagata, R Kagotani, S Tanaka, H Kawaguchi, K Nakamura, T Akune M Yoshida
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Journal Title
The Spine Journal
Volume: 15
Pages: 622-628
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study2014
Author(s)
M Teraguchi, N Yoshimura, H Hashizume, S Muraki, H Yamada, H Oka, A Minamide, Y Ishimoto, K Nagata, R Kagotani, N Takiguchi, T Akune, H Kawaguchi, K Nakamura, M Yoshida
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Journal Title
Osteoarthritis and Cartilage
Volume: 22
Pages: 104-110
Related Report
Peer Reviewed
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[Presentation] Diabetes mellitus is a significant risk factor for lumbar disc degeneration in a longitudinal population- based cohort: the Wakayama Spine Study2016
Author(s)
M Teraguchi, N Yoshimura, H Hashizume, S Muraki, H Yamada, H Oka, A Minamide, K Nagata, Y Ishimoto, R Kagotani, M Yoshida..
Organizer
International society for study of lumbar spine
Place of Presentation
Singapore
Year and Date
2016-05-16
Related Report
Int'l Joint Research
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[Presentation] Associations between types of Modic changes in the lumbar region and lower back pain in a large cohort in Japan: the Wakayama Spine Study2015
Author(s)
M Teraguchi, N Yoshimura, H Hashizume, S Muraki, H Yamada, H Oka, A Minamide, Y Nakagawa, Y Ishimoto, K Nagata, R Kagotani, S Tanaka, H Kawaguchi, K Nakamura, T Akune, M Yoshida.
Organizer
The International Society for the Study of the Lumbar Spine
Place of Presentation
サンフランシスコ(アメリカ)
Year and Date
2015-06-08
Related Report
Int'l Joint Research
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[Presentation] Metabolic syndrome components are associated with the intervertebral disc degeneration: the Wakayama Spine Study2015
Author(s)
M Teraguchi, N Yoshimura, H Hashizume, S Muraki, H Yamada, H Oka, A Minamide, Y Nakagawa, Y Ishimoto, K Nagata, R Kagotani, S Tanaka, H Kawaguchi, K Nakamura, T Akune, M Yoshida.
Organizer
Asia pacific spine society
Place of Presentation
香港(中国)
Year and Date
2015-06-05
Related Report
Int'l Joint Research
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[Presentation] Atherosclerotic risk factors and intervertebral disc degeneration in the entire spine in a population-based cohort: The Wakayama Spine Study2014
Author(s)
M Teraguchi, N Yoshimura, H Hashizume, S Muraki, H Yamada, H Oka, Y Ishimoto, K Nagata, R Kagotani, T Akune, M Yoshida.
Organizer
第87回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2014-05-21 – 2014-05-25
Related Report
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[Book] 臨床整形外科2017
Author(s)
1.寺口 真年, 橋爪 洋, 山田 宏, 吉村 典子, 吉田 宗人
Total Pages
4
Publisher
医学書院
Related Report