Effects of neurosteroid on pain transmission in the rat dorsal horn.

Research Project

Project/Area Number	26861224
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Niigata University
Principal Investigator	YAMAMOTO Goh 新潟大学, 医歯学総合病院, 医員 (40710463)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	神経ステロイド / デヒドロエピアンドロステロンサルフェート / 脊髄後角 / シグマ1受容体 / 痛覚過敏 / シグマ１受容体
Outline of Final Research Achievements	Dehydroepiandrosterone sulfate (DHEAS) is a kind of neurosteroids and is known to have pronociceptive effects on the spinal cord. However, its underlying mechanisms has not been elucidated.We investigated the effect of DHEAS on excitatory synaptic transmission in the dorsal horn neurons of the adult rat spinal cord using electrophysiological technique.We demonstrated that DHEAS enhanced excitatory transmission and suppressed inhibitory transmission in spinal lamina II neurons, resulting in showing pronociceptive effects on the spinal cord.

Report

(3 results)