| Project/Area Number |
26861230
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Amato Marcelo B. P. University of São Paulo Medical School, Pulmonary Division, 教授
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | ARDS / 人工呼吸 / 人工呼吸器関連肺傷害 / 人工呼吸管理 / 急性呼吸促迫症候群 / 人工呼吸関連肺傷害 |
|---|
| Outline of Final Research Achievements |
The vigorous spontaneous effort during mechanical ventilation in severe ARDS will cause ventilator-induced lung injury, contributing to increased mortality in ARDS. Thus, short term use of muscle paralysis was proven to reduce the motality of severe ARDS, but alternative strategy is needed considering it will potentially be associated with muscle weekness.
This study shows that the application of PEEP can reduce spontaneous breathing, leading to better distribution of lung aeration in CT, and less histological lung injury. This is the first demonstration that we can reduce the harm of spontaneous breathing in severe ARDS without paralyzing patients. This will be quite important because we can minimize the spontaneous breathing associated lung injury, but with preserving muscle function.
|
