The association of cardiac biomarkers and postoperative serious adverse events in pediatric cardiac patients

• Project/Area Number: 26861233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Okayama University
• Principal Investigator: Kanazawa Tomoyuki 岡山大学, 大学病院, 助教 (80457217)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: BNP / 小児心臓 / 術後合併症 / 術後管理 / 小児心臓手術 / 周術期 / 心臓バイオマーカー / 心拍出量 / 患者予後 / 集中治療室

Outline of Final Research Achievements

I investigated the relationship between Brain Natriuretic Peptide and post operative serious adverse events in pediatric cardiac surgery. This study resulted that preoperative BNP was associated with the occurrence of postoperative serious adverse events. postoperative BNP did not have the relationship with postoperative serious adverse events. I did next study to investigated the role of postoperative BNP measurements in pediatric cardiac surgery. The second study was prospective multi center study in Japan. The second study showed that pediatric cardiac intensivists measured BNP when they wanted to know the value of BNP. There was no hospital to have the protocol of postoperative BNP measurement.The main result of this study was that the pediatric intensivists intervened for patients when postoperative BNP was higher than 2000pg/ml

Research Products

• [Journal Article] Perioperative Brain Natriuretic Peptide In Pediatric Cardiac Surgery Patients: Its Association With Postoperative Outcomes. (2017)
  • Author(s): Kanazawa T, Egi M, Toda Y, Shimizu K, Sugimoto K, Iwasaki T, Morimatsu H.
  • Journal Title: J Cardiothorac Vasc Anesth. Volume: Apr;31(2) Issue: 2 Pages: 537-542
  • DOI: 10.1053/j.jvca.2016.09.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intraoperative change of lactate level is associated with postoperative outcomes in pediatric cardiac surgery patients: retrospective observational study. (2016)
  • Author(s): Kanazawa T, Egi M, Shimizu K, Toda Y, Iwasaki T, Morimatsu H.
  • Journal Title: BMC Anesthesiology Volume: Mar Issue: 1
  • DOI: 10.1186/s12871-015-0007-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraoperative change of lactate level is associated with postoperative outcomes in pediatric cardiac surgery patients: retrospective observational study (2015)
  • Author(s): Tomoyuki Kanazawa
  • Journal Title: BMC Anesthesiology Volume: 15 Pages: 1-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The evaluation and intervention for postoperative brain natriuretic peptide concentration in pediatric cardiac patients: multicenter study in Japan (2017)
  • Author(s): Tomoyuki Kanazawa
  • Organizer: ESICM2017
  • Int'l Joint Research
• [Presentation] 慢性期から周術期へBNPの臨床的意義と小児心臓手術における役割 (2017)
  • Author(s): 金澤伴幸
  • Organizer: 日本心臓血管麻酔学会第22回学術大会
• [Presentation] 心臓バイオマーカーを周術期急性心不全の診断と治療にとりいれる（BNPの臨床応用） (2015)
  • Author(s): 金澤伴幸
  • Organizer: 日本麻酔科学会第６２回学術集会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2015-05-28
• [Presentation] PREOPERATIVE BRAIN NATRIURETIC PEPTIDE IN PEDIATRIC CARDIAC SURGERY PATIENTS: ITS ASSOCIATION WITH POSTOPERATIVE OUTCOMES (2015)
  • Author(s): Tomoyuki Kanazawa
  • Organizer: International Anesthesia Research Society
  • Place of Presentation: Hawaii
  • Year and Date: 2015-03-21 – 2015-03-23