Contribution of TRPA1 to arousal and respiratory activation to hypoxia
| Project/Area Number |
26861234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Kuroki Chiharu 鹿児島大学, 医学部・歯学部附属病院, 医員 (20725650)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | TRPA1 / 低酸素 / 鼻腔三叉神経 / 三叉神経 / 覚醒 / 呼吸 |
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| Outline of Final Research Achievements |
We hypothesized that TRPA1 detect oxygen concentration in inspired gas and respiratory regulation, as early alarm system. We revealed that pathway trough TRPA1 contribute to arousal from sleep and respiratory activation, as a defensive response to hypoxia. Pathway trough TRPA1 suggested to locate on the trigeminal nerve in nasal cavity. This defense response is more important in mild hypoxia than severe hypoxia. We concluded TRPA1 is an early alarm system for hypoxia in airway.
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Report
(3 results)
Research Products
(8 results)
