Mechanisms for antinociceptive effect of beta-edorphin on the spinal dorsal horn.
| Project/Area Number |
26861247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | βエンドルフィン / オピオイド受容体 / サブスタンスP / 脊髄後角 / 内因性鎮痛 / 急性炎症モデル / NK1受容体 / c-Fos / NK１受容体 |
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| Outline of Final Research Achievements |
To further elucidate the mechanisms for antinociceptive effects of beta-endorphin on spinal dorsal horn, we evaluated the effects of beta-endorphin with or without selective opioid receptor antagonists on formalin-induced acute pain model. Intrathecal beta-endorphin inhibited the release of substance P from primary afferent (presynaptic): neurokinin 1 receptor internalization reflects release of substance P, mu-antagonist reversed the effects, but delta-antagonists did not reverse. This result implied that antinociceptive effects for beta-endorphin through delta-opioid receptor associated with another substance P release from primary afferent mechanism.
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Report
(3 results)
Research Products
(5 results)
