| Project/Area Number |
26861247
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Dokkyo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | βエンドルフィン / オピオイド受容体 / サブスタンスP / 脊髄後角 / 内因性鎮痛 / 急性炎症モデル / NK1受容体 / c-Fos / NK１受容体 |
|---|
| Outline of Final Research Achievements |
To further elucidate the mechanisms for antinociceptive effects of beta-endorphin on spinal dorsal horn, we evaluated the effects of beta-endorphin with or without selective opioid receptor antagonists on formalin-induced acute pain model. Intrathecal beta-endorphin inhibited the release of substance P from primary afferent (presynaptic): neurokinin 1 receptor internalization reflects release of substance P, mu-antagonist reversed the effects, but delta-antagonists did not reverse. This result implied that antinociceptive effects for beta-endorphin through delta-opioid receptor associated with another substance P release from primary afferent mechanism.
|
