Modulation of neural circuits by volatile anesthetic in the mouse brain during postnatal development and senium
| Project/Area Number |
26861249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 吸入麻酔薬 / 脳内神経伝達 / 過分極活性化陽イオン電流 |
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| Outline of Final Research Achievements |
Volatile anesthetics have been reported to inhibit the hyperpolarization-activated cation current (Ih) that contributes to generation of synchronized oscillatory neural rhythms. Meanwhile, the developmental change of Ih has been speculated to play a pivotal role during maturation. We examined the effect of volatile anesthetic sevoflurane on Ih in developing striatum. Our analyses showed that the changes in Ih of cholinergic interneurons occurred in conjunction with maturation. In addition, sevoflurane caused significant inhibition of Ih in a dose-dependent manner. Moreover, sevoflurane significantly decreased spike firing during the rebound activation, which is essential for responses to the sensory inputs from the cortex and thalamus. The sevoflurane-induced inhibition of Ih in striatal cholinergic interneurons may lead to alterations of the acetylcholine-dopamine balance in the neural circuits during the early postnatal period.
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Report
(4 results)
Research Products
(25 results)
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[Presentation] 外来受診患者での腰痛における仙腸関節由来の痛みの頻度2014
Author(s)
吉川博昭, 酒井大介, 榎本達也, 菅澤佑介, 原 厚子, 今井美奈, 松本園子, 中村かんな, 松岡芙美, 光畑裕正
Organizer
日本ペインクリニック学会 第48回大会
Place of Presentation
京王プラザホテル・新宿
Year and Date
2014-07-24 – 2014-07-26
Related Report
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[Presentation] 高齢者の腰痛に対する疎経活血湯と十全大補湯の有用性2014
Author(s)
光畑裕正, 松本園子, 原 厚子, 飯田史絵, 菅澤佑介, 榎本達也, 今井美奈, 小西るり子, 松岡芙美, 酒井大輔, 中村かんな
Organizer
第27 回日本疼痛漢方研究会学術集会
Place of Presentation
東京コンファレンスセンター・品川
Year and Date
2014-07-05
Related Report
