Investigation of the role in the bladder of the P2Y receptor
| Project/Area Number |
26861264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KIRA Satoru 山梨大学, 総合研究部, 助教 (10530115)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 排尿障害 / P2Y受容体 / 膀胱 / 知覚神経伝達 / 過活動膀胱 / 泌尿器科学 / 排尿生理学 / ATP / プリン受容体 |
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| Outline of Final Research Achievements |
We investigated lower urinary tract function of P2Y6R knockout (P2Y6KO) mice and compared to that of the wild-type mice. In micturition behaviors, P2Y6KO mice exhibited higher voiding frequency and smaller urine volume/void. In cystometrogram study, P2Y6KO mice had smaller bladder capacity with lower compliance. In organ bath study, there was no significant difference in contraction and/or relaxation of the bladder smooth muscles. These results suggested that the P2Y6R regulated bladder storage function.
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Report
(3 results)
Research Products
(13 results)
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[Presentation] ﾏｳｽ膀胱平滑筋・上皮におけるP2Y6受容体機能の検討2015
Author(s)
吉良 聡, 芳山 充晴, 宮本 達也, 井原 達矢, 中込 宙史, 望月 勉, 澤田 智史, 柴田 圭輔, 繁冨 英治, 小泉 修一, 武田 正之
Organizer
第103回日本泌尿器科学会総会
Place of Presentation
ホテル金沢（石川県金沢市）
Year and Date
2015-04-18
Related Report
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