Analysis of Prostate cancer-related exosome
Project/Area Number |
26861265
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Gifu University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 前立腺癌 / エクソソーム |
Outline of Final Research Achievements |
There is a great need of the development of novel diagnostic strategies that target the castration-resistant prostate cancer. One of the potential strategies is the use of microvesicles including exosomes secreted from prostate cancer cells as a tool for diagnosis. Prostate cancer related exosome included androgen receptor. mRNA analysis of prostate cancer-related exosome derived from prostate cancer cell line showed that androgen receptor and its variant were detectable. Antibody conjugated beads was capable of isolation of prostate cancer-related exosomes from patient’s blood. The results showed that the amount of isolated exosomes was higher in advanced and chemo-resistant prostate cancer patients than in prostate cancer patients without metastasis and healthy volunteers. Overall, this study showed that analysis of prostate cancer-related exosomes will enhance the research on prostate cancer.
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Report
(3 results)
Research Products
(4 results)