Crosstalk between epithelial-mesenchymal transition and castration resistance in prostate cancer

• Project/Area Number: 26861273
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kyushu University
• Principal Investigator: Shiota Masaki 九州大学, 医学(系)研究科(研究院), 助教 (20635445)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺癌 / 去勢抵抗性 / 上皮間葉転換

Outline of Final Research Achievements

This study aimed to figure out the interaction between epithelial-mesenchymal transition and castration resistance, and to apply it to clinics. As a result, Twist1/androgen receptor signaling molecularly mediated crosstalk between epithelial-mesenchymal transition and castration resistance. As well, an inhibitor for epithelial-mesenchymal transition combined with androgen-deprivation therapy seems to be a promising therapeutic to prostate cancer.

Research Products

• [Journal Article] Secondary bladder cancer after anticancer therapy for prostate cancer; reduced comorbidity after androgen-deprivation therapy (2015)
  • Author(s): Shiota M, Yokomizo A, Takeuchi A, Imada K, Kiyoshima K, Inokuchi J, Tatsugami K, Ohga S, Nakamura K, Honda H, Naito S
  • Journal Title: Oncotarget Volume: 6 Issue: 16 Pages: 14710-14719
  • DOI: 10.18632/oncotarget.3817
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer (2015)
  • Author(s): Shiota M, Bishop J, Takeuchi A, Nip KM, Cordonnier T, Beraldi E, Kuruma H, Gleave ME, Zoubeidi A
  • Journal Title: Oncotarget Volume: ６ Issue: 11 Pages: 9086-9098
  • DOI: 10.18632/oncotarget.3602
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SRD5A gene polymorphism in Japanese men predicts prognosis of metastatic prostate cancer with androgen-deprivation therapy. (2015)
  • Author(s): Shiota M, Fujimoto N, Yokomizo A, Takeuchi A, Itsumi M, Inokuchi J, Tatsugami K, Uchiumi T, Naito S.
  • Journal Title: Eur J Cancer Volume: 51 Issue: 14 Pages: 1962-9
  • DOI: 10.1016/j.ejca.2015.06.122
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Crosstalk between epithelial-mesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer (2015)
  • Author(s): Masaki Shiota, Momoe Itsumi, Ario Takeuchi, Kenjiro Imada, Akira Yokomizo, Hidetoshi Kuruma, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi, Yoshinao Oda, Seiji Naito
  • Journal Title: Endocrine-related cancer Volume: 22 Issue: 6 Pages: 889-900
  • DOI: 10.1530/erc-15-0225
  • Peer Reviewed
• [Journal Article] Low Serum Testosterone But Not Obesity Predicts High Gleason Score at Biopsy Diagnosed as Prostate Cancer in Patients with Serum PSA Lower than 20 ng/ml (2015)
  • Author(s): Shiota M, Takeuchi A, Sugimoto M, Dejima T, Kashiwagi E, Kiyoshima K, Inokuchi J, Tatsugami K, Yokomizo A
  • Journal Title: Anticancer Research Volume: 35 Pages: 6137-6145
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic Impact of Serum Testosterone and Body Mass Index Before Androgen-deprivation Therapy in Metastatic Prostate Cancer (2015)
  • Author(s): Shiota M, Takeuchi A, Sugimoto M, Kashiwagi E, Dejima T, Kiyoshima K, Inokuchi J, Tatsugami K, Yokomizo A
  • Journal Title: Anticancer Research Volume: 35 Pages: 6925-6932
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Crosstalk between EMT and castration resistance mediated by Twist1/androgen receptor signaling in prostate cancer (2015)
  • Author(s): Shiota M, Itsumi M, Takeuchi A, Yokomizo A, Kuruma H, Inokuchi J, Tatsugami K, Uchiumi T, Oda Y, Naito S
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-10
• [Presentation] Equol promotes protein degradation of androgen receptor via Skp2 and suppresses cell proliferation in prostate cancer (2015)
  • Author(s): Itsumi M, Shiota M, Takeuchi A, Kashiwagi E, Inokuchi J, Tatsugami K, Kajioka S, Uchiumi T, Naito S, Yokomizo A
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 前立腺癌の進展と治療抵抗性機序の解明と臨床応用―前立腺癌の統合的理解を目指して― (2015)
  • Author(s): 塩田真己
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-04-18 – 2015-04-21
  • Invited