Research Project
Grant-in-Aid for Young Scientists (B)
BCG is used for the treatment of bladder cancer. The recruitment of neutrophlis to the bladder after BCG instillation exerts anti-tumor activity against bladder tumor. We have recently demonstrated that interleukin (IL)-17A produced by gamma-delta (gd) T cells played a role in the recruitment of neutrophlis to the bladder after BCG instillation. We previously constructed a recombinant BCG strain expressing the fusion protein of IL-15 and Ag85B (BCG-IL-15) for prevention of Mycobacterium tuberculosis infection. Here we compared the efficacy of the BCG-IL-15 in protection against bladder cancer with that of rBCG-Ag85B (BCG).BCG-IL-15 treatment significantly prolonged survival of mice inoculated with bladder cancer cells compared with BCG treatment. Infiltration of neutrophils was significantly elevated in BCG-IL-15 treated mice accompanied by increased chemokinesin the bladder. Thus, BCG-IL-15 exerted additive effect on Infiltration of neutrophils in the bladder.
All 2016
All Journal Article (1 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 1 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)
Cancer Sci
Volume: in press Pages: 327-331
10.1016/j.intimp.2016.03.007
