| Project/Area Number |
26861279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 過活動膀胱 / Rho-kinase / 慢性膀胱虚血 |
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| Outline of Final Research Achievements |
Recent studies have suggested that aging-associated changes in pelvic vasculature such as atherosclerosis eventually result in chronic bladder ischemia, which may play a key role in the development of lower urinary tract symptoms. Currently, it has been shown that the RhoA/Rho-kinase (ROK) pathway is substantially involved in the pathogenesis of atherosclerosis.The aim of study is to investigate the effect of fasudil, a ROK inhibitor, on chronic ischemia-related bladder dysfunction by using a rat model of chronic bladder ischemia.The present results suggest that chronic treatment with fasudil may prevent neointimal formation and chronic ischemia-related bladder dysfunction, resulting in improvement of bladder hyperactivity.
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