Elucidation of the mechanism of the kidney stone formation inhibited by adiponectin and its application to treatment
Project/Area Number |
26861282
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Nagoya City University |
Principal Investigator |
Fujii Yasuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (30566229)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | メタボリックシンドローム / 腎結石 / アディポネクチン / 尿路結石 |
Outline of Final Research Achievements |
The only ob/ob mice showed crystal depositions in their renal tubules. Expression analysis of genes associated with MetS-related kidney stone formation identified 259 genes that were >2.0× up-regulated and 243 genes that were <0.5× down-regulated. GO analyses revealed that the up-regulated genes belonged to the categories of immunoreaction, inflammation, and adhesion molecules. The down-regulated genes belonged to the categories of oxidative stress and lipid metabolism. Expression analysis of APN-induced genes related to stone prevention revealed that the numbers of up- and down-regulated genes were 154 and 190, respectively. GO analyses indicated that the up-regulated genes belonged to the categories of cellular and mitochondrial repair, whereas the down-regulated genes belonged to the categories of immune and inflammatory reactions and apoptosis.
|
Report
(4 results)
Research Products
(20 results)
-
-
[Presentation] Inhibitory effect of Rooibos tea on urinary stone formation in a rat model.2016
Author(s)
Hirose Yasuhiko, Taguchi Kazumi, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Kobayashi Takahiro, Hirose Masahito, Okada Atsushi, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro, Mokoena Mpho, Rodgers Allen
Organizer
13th International Symposium on Urolithiasis
Place of Presentation
幕張メッセ(千葉県千葉市)
Year and Date
2016-07-19
Related Report
Int'l Joint Research
-
[Presentation] Effects of atherosclerosis-related factors on renal crystal formation in a mouse model of metabolic syndrome.2016
Author(s)
Fujii Yasuhiro, Okada Atsushi, Taguchi Kazumi, Ito Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Ando Ryosuke, Itoh Yasunori, Sakakura Takeshi, Kohri Kenjiro, Yasui Takahiro
Organizer
13th International Symposium on Urolithiasis
Place of Presentation
幕張メッセ(千葉県千葉市)
Year and Date
2016-07-19
Related Report
Int'l Joint Research
-
[Presentation] Nnt gene suppresses kidney stone formation and oxidative stress.2016
Author(s)
Usami Masayuki, Fujii Yasuhiro, Hirose Yasuhiko, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Itoh Yasunori, Tozawa Keiichi, Gao Bing, Kohri Kenjiro, Yasui Takahiro
Organizer
13th International Symposium on Urolithiasis
Place of Presentation
幕張メッセ(千葉県千葉市)
Year and Date
2016-07-19
Related Report
Int'l Joint Research
-
-
-
-
[Presentation] Identification of urinary macrophage-related factors specific to patients with calcium oxalate stones using multiplex analysis.2016
Author(s)
Okada Atsushi, Taguchi Kazumi, Fujii Yasuhiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Yasui Takahiro
Organizer
American Urological Association Annual Meeting 2016
Place of Presentation
San Diego (USA)
Year and Date
2016-05-06
Related Report
Int'l Joint Research
-
[Presentation] Different roles of M1/M2 macrophage phenotype for renal crystal formation.2016
Author(s)
Taguchi Kazumi, Okada Atsushi, Unno Rei, Fujii Yasuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Ando Ryosuke, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
Organizer
American Urological Association Annual Meeting 2016
Place of Presentation
San Diego (USA)
Year and Date
2016-05-06
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-