| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The only ob/ob mice showed crystal depositions in their renal tubules. Expression analysis of genes associated with MetS-related kidney stone formation identified 259 genes that were >2.0× up-regulated and 243 genes that were <0.5× down-regulated. GO analyses revealed that the up-regulated genes belonged to the categories of immunoreaction, inflammation, and adhesion molecules. The down-regulated genes belonged to the categories of oxidative stress and lipid metabolism. Expression analysis of APN-induced genes related to stone prevention revealed that the numbers of up- and down-regulated genes were 154 and 190, respectively. GO analyses indicated that the up-regulated genes belonged to the categories of cellular and mitochondrial repair, whereas the down-regulated genes belonged to the categories of immune and inflammatory reactions and apoptosis.
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