Development of thermotherapy using magnetic nanoparticles for bladder cancer and elucidation of its healing mechanism

Research Project

Project/Area Number	26861283
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Nagoya City University
Principal Investigator	KOBAYASHI Daichi 名古屋市立大学, 大学院医学研究科, 研究員 (80570704)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	MCL / 膀胱がん / 温熱治療 / MCL thermotherapy / 免疫 / Thermotherapy / MCL Thermotherapy
Outline of Final Research Achievements	We have developed a new treatment method (MCL Thermotherapy) that can specifically warm cancer lesions using magnetic nanoparticles and reported the therapeutic effect on various cancers. We examined the effectiveness of MCL Thermotherapy against bladder cancer this time. MCL has high cell affinity and proved to be significant adsorption to bladder cells. Moreover, not only direct tumor shrinkage effect but also enhancement of tumor immunity via immunity induction cytokine was observed. MCL thermotherapy proved to be an effective treatment for highly sensitive bladder cancer of immunotherapy.

Report

(4 results)