The role of perioperative circulating tumor cell in patients undergoing prostate radiotherapy
Project/Area Number |
26861293
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Kitasato University |
Principal Investigator |
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Research Collaborator |
SATOH Takefumi
TABATA Ken-ichi
ISHIYAMA Hiromichi
NAKAMURA Masaki
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 前立腺癌 / 放射線治療 / 密封小線源療法 / 血中循環腫瘍細胞 / 医原性播種 / 血行性転移 / CTC / 遠隔転移 / 密封小線源 / 上皮細胞接着分子 / 播種 |
Outline of Final Research Achievements |
Despite the absence of local prostate cancer recurrence, some patients develop distant metastases after prostate brachytherapy. We evaluate whether prostate brachytherapy procedures have a potential risk for hematogenous spillage of prostate cancer cells. While no preoperative samples showed circulating tumor cells (CTCs) (0%), they were detected in intraoperative samples in 7 of the 59 patients(11.8%). We detected CTCs from samples immediately after the surgical manipulation. Further study is needed to evaluate whether those CTCs actually can survive and proliferate at distant sites.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Prostate-specific antigen nadir after high-dose-rate brachytherapy predicts long-term survival outcomes in high-risk prostate cancer.2016
Author(s)
Tsumura H, Satoh T, Ishiyama H, Tabata K, Komori S, Sekiguchi A, Ikeda M, Kurosaka S, Fujita T, Kitano M, Hayakawa K, Iwamura M.
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Journal Title
Journal of Contemporary Brachytherapy
Volume: 8
Pages: 95-103
DOI
Related Report
Open Access
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[Journal Article] Dosimetry of permanent interstitial prostate brachytherapy for an interoperative procedure, using O-arm based CT and TRUS.2016
Author(s)
Hiromichi Ishiyama, Akane Sekiguchi, Takefumi Satoh, Hideyasu Tsumura, Kouji Takenaka, Shogo Kawakami, Ken-ichi Tabata, Kentaro Kobayashi, Masatsugu Iwamura, Kazushige Hayakawa
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Journal Title
Journal of Contemporary Brachytherapy
Volume: 8
Pages: 7-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Very-high-risk前立腺癌に対する内分泌療法と外照射併用によるHDR brachytherapyの有用性2015
Author(s)
津村 秀康, 佐藤 威文, 石山 博條, 田畑 健一, 北野 雅史, 黒坂 眞二, 関口 茜衣, 川上 正悟, 小森 承子, 早川 和重, 岩村 正嗣
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Journal Title
泌尿器外科
Volume: 28
Pages: 623-625
Related Report
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[Journal Article] Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy2015
Author(s)
Hideyasu Tsumura, Takefumi Satoh, Hiromichi Ishiyama, Shuhei Hirano, Ken-ichi Tabata, Shinji Kurosaka, Kazumasa Matsumoto, Tetsuo Fujita, Masashi Kitano, Shiro Baba, Kazushige Hayakawa, Masatsugu Iwamura
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Journal Title
World Journal of Radiology
Volume: 7
Issue: 12
Pages: 494-500
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer2016
Author(s)
Hideyasu Tsumura,Takefumi Satoh,Ken-ichi Tabata,Hiromichi Ishiyama,Sho Watanuki,Yusuke Sakata,Akane Sekiguchi,Mizuho Kawamura,Masashi Kitano,Tetsuo Fujita,Kazushige Hayakawa,Masatsugu Iwamura
Organizer
WORLD CONGRESS OF BRACHYTHERAPY
Place of Presentation
USA, San Francisco
Year and Date
2016-06-29
Related Report
Int'l Joint Research
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