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Investigation of anti-tumor effect of Axl kinase inhibitor in urothelial carcinoma.

Research Project

Project/Area Number 26861296
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKeio University

Principal Investigator

Hattori Seiya  慶應義塾大学, 医学部, 助教 (80464907)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsAxl / Gas6 / Urotherial carcinoma / 尿路上皮癌 / UTUC / prognosis
Outline of Final Research Achievements

We analyzed Axl-Gas6 signal cascade using both UMUC3 and HT1376 cell lines, which are commercially purchasable UC cell lines. We used Western blotting analysis and immune-staining analysis. HT1376 is weak Axl-staining cell line and UMUC3 is a weak Axl-staining cell line. Commercially purchasable Axl kinase inhibitor, R428, had no cytotoxic ability in itself, but it blocks invasive capacity store-dependently in UMUC3 cell line. The protein expression of Axl and Gas6 by immunohistochemistry and its correlation with clinicopathologic features were investigated in surgical specimens obtained from patients who had been surgically treated for UTUC. Axl protein expression and its ligand Gas6 protein expression associate with each other, and both of them highly associated with worse prognosis of UTUC patients treated by radical nephroureterectomy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Relationship between increased expression of the Axl/Gas6 signal cascade and prognosis of patients with upper tract urothelial carcinoma.2016

    • Author(s)
      Hattori S, Kikuchi E, Kosaka T, Miyazaki Y, Tanaka N, Miyajima A, Mikami S, Oya M
    • Journal Title

      Ann Surg Oncol

      Volume: 23 Issue: 2 Pages: 663-670

    • DOI

      10.1245/s10434-015-4848-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Relationship between increased expression of Axl-Gas6 signal cascade and prognosis in upper urinary tract urothelial carcinoma.2015

    • Author(s)
      服部盛也、菊地栄次、小坂威雄、、宮嶋哲、三上修治、大家基嗣
    • Organizer
      2015 Annual Meeting of the American Urological Association
    • Place of Presentation
      ニューオリンズ コンフォートセンター
    • Year and Date
      2015-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Relationship between increased expression of Axl-Gas6 signal cascade and prognosis in upper urinary tract urothelial carcinoma2015

    • Author(s)
      Seiya Hattori, Eiji Kikuchi, Takeo Kosaka, Akira Miyajima, Shuji Mikami, Mototsugu Oya
    • Organizer
      2015 American Urological Association (AUA) Annual Meeting
    • Place of Presentation
      ニューオリンズ(アメリカ)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AXL-Gas6カスケード亢進と上部尿路上皮癌術後の予後との関連2015

    • Author(s)
      服部盛也、菊地栄次、小坂威雄、、宮嶋哲、三上修治、大家基嗣
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      金沢市 石川県立音楽堂
    • Year and Date
      2015-04-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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