New strategy of Identifying a candidate drug of reprogramming prostate cancer by targeting gene network
Project/Area Number |
26861299
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Keio University |
Principal Investigator |
KOSAKA TAKEO 慶應義塾大学, 医学部, 講師 (30445407)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 前立腺癌 / 幹細胞 / 薬剤耐性 / 去勢抵抗性前立腺癌 / C4-2AT6 / バイオインフォマティクス / ドラッグリポジショニング / リプログラミング療法 / CRPC / 再プログラム化 / がん幹細胞 / 遺伝子ネットワーク / リプログラミング / アンドロゲン |
Outline of Final Research Achievements |
Recently, new generation anti-androgen drugs and a new generation taxane, cabazitaxel have received a lot of attention as high potent agents for CRPC. However, response rate and overall survival benefit of these drugs are limited. In this study, we investigated gene expression profiles of prostate cancer using the whole human genome microarray and compared using Connectivity Map to identify candidate drugs with the potential to revert tumor’s metastatic properties. We found a candidate drug that can possibly overcome refractory prostate cancer.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Should We Try Antiandrogen Withdrawal in Castration-Resistant Prostate Cancer Patients? Insights From a Retrospective Study.2016
Author(s)
Hongo H, Kosaka T, Mizuno R, Ezaki T, Matsumoto K, Morita S, Shinoda K, Shinojima T, Kikuchi E, Miyajima A, Oya M.
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Journal Title
Clinical Genitourinary Cancer
Volume: Epub ahead of print
Issue: 6
Pages: e569-e573
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 常識を疑う前立腺癌の挙動2015
Author(s)
小坂 威雄
Organizer
第3回泌尿器画像診断・治療技術研究会
Place of Presentation
ウェスティン都ホテル京都(京都府京都市)
Year and Date
2015-09-26
Related Report
Invited
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