To uncover the pathogenesis of preeclampsia.

Research Project

Project/Area Number	26861308
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Obstetrics and gynecology
Research Institution	National Center for Child Health and Development (2016) Yamagata University (2014-2015)
Principal Investigator	Amita Mitsuyoshi 国立研究開発法人国立成育医療研究センター, 周産期・母性診療センター, 医員 (30420061)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	妊娠高血圧症候群 / iPS細胞 / trophoblast / fibroblast / 妊娠高血圧症
Outline of Final Research Achievements	One of the cause of preeclampsia is thought to be poor placentation developed in early pregnancy. Understanding the pathogenesis of the diseases has been hampered by inaccessibility to the early stages of human placental tissue. In this study, we examined to derive iPSC from human umbilical cord and differentiate into trophoblast. Longer term goal is to generate iPSC from umbilical cords of preeclampsia patients to generate abnormal placental models to uncover the mechanisms of the disease.

Report

(4 results)