Effect of stress response in endometriosis
| Project/Area Number |
26861313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HASEGAWA AKIKO 東京大学, 医学部附属病院, 臨床登録医 (50598159)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 子宮内膜症 / 慢性炎症 |
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| Outline of Final Research Achievements |
To investigate the effect of drospirenone(D) on human eutopic emdometrial(EuSC) and ectopic(EcSC) endomemetriotic stromal cells.EuSC and EcSC were treated with D. D induced decidualization in EuSC, and induction was negated by RU486. D reduced DNA synthesis on EcSC, and negated by RU486, but not by aldosterone or mineralocorticoid receptor silencing.
To investigate a role of interleukin (IL)-17A in endometriosis. IL17A increased the secretion of Groα from EcSCs. The conditioned medium of EcSCs stimulated with IL17A attracted neutrophils. On immunostaining, IL17A and Groα were detected in similar areas of the stroma beneath the epithelium. Fluorescent immunostaining corroborated that MPO-positive neutrophils were also positive for IL17A. In mice endometriosis model, neutrophils were depleted by antiGr1 antibody, either in the early (E)or late (L)stage. The number of endometriotic lesions was significantly less in group E.
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Report
(3 results)
Research Products
(12 results)
