The role of seminal fuid in paternal antigen specific feto-maternal tolerance

• Project/Area Number: 26861316
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: Shima Tomoko 富山大学, 医学薬学研究部(医学), 助教 (00377285)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 精漿 / 父親抗原特異的制御性T細胞 / 免疫寛容誘導性樹状細胞 / 母児免疫寛容 / 制御性T細胞 / 制御性樹状細胞

Outline of Final Research Achievements

Fetus is a semi-allograft to maternal immune system. We have shown that paternal antigen specific regulatory T cells have an active role for feto-maternal tolerance. And, it is known that antigen specific regulatory T cells are induced after antigen presentation by tolerogenic dendritic cells (DC).
We analyzed the role of seminal fuid in paternal antigen specific feto-maternal tolerance with focused on paternal antigen specific Treg and tolerogenic DC.
Seminal fluid priming is important for the induction of tolerogenic DC and patarnal antigen specific Treg. The crosstalk of DC and Treg is important for success of pregnancy.

Research Products

• [Journal Article] Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancy. (2015)
  • Author(s): Shima T, Inada K, Nakashima A, Ushijima A, Ito M, Yoshino O, Saito S.
  • Journal Title: J Reprod Immunol. Volume: 108 Pages: 78-82
  • DOI: 10.1016/j.jri.2015.02.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Paternal antigen specific-regulatory T cells are induced by tolerogeneic DCs after seminal plasma priming (2016)
  • Author(s): Tomoko Shima, Kumiko Inada, Akemi Ushijima, Akitoshi Nakashima, Osamu Yoshino, Shigeru Saito
  • Organizer: 13th Congress of the International Society for Immunology of Reproduction and the European Society for Reproductive Immunology
  • Place of Presentation: Erfurt、Germany
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] 精漿によるプライミングによる父親抗原特異的母児免疫寛容の誘導 (2015)
  • Author(s): 島友子、稲田 貢三子、牛島明美、伊藤実香、中島彰俊、吉野修、齋藤滋
  • Organizer: 第67日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09 – 2015-04-12
• [Presentation] 精漿によるプライミングによる父親抗原特異的母児免疫寛容の誘導 (2015)
  • Author(s): 島友子、稲田貢三子、牛島明美、伊藤実香、中島彰俊、吉野修、齋藤滋
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09
• [Presentation] 精漿によるプライミングは抑制性樹状細胞を誘導しトレランスを確立し妊娠成立に関与する (2014)
  • Author(s): 島友子、稲田貢三子、中島彰俊、吉野修、齋藤滋
  • Organizer: 第66日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20