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The role of seminal fuid in paternal antigen specific feto-maternal tolerance

Research Project

Project/Area Number 26861316
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

Shima Tomoko  富山大学, 医学薬学研究部(医学), 助教 (00377285)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords精漿 / 父親抗原特異的制御性T細胞 / 免疫寛容誘導性樹状細胞 / 母児免疫寛容 / 制御性T細胞 / 制御性樹状細胞
Outline of Final Research Achievements

Fetus is a semi-allograft to maternal immune system. We have shown that paternal antigen specific regulatory T cells have an active role for feto-maternal tolerance. And, it is known that antigen specific regulatory T cells are induced after antigen presentation by tolerogenic dendritic cells (DC).
We analyzed the role of seminal fuid in paternal antigen specific feto-maternal tolerance with focused on paternal antigen specific Treg and tolerogenic DC.
Seminal fluid priming is important for the induction of tolerogenic DC and patarnal antigen specific Treg. The crosstalk of DC and Treg is important for success of pregnancy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancy.2015

    • Author(s)
      Shima T, Inada K, Nakashima A, Ushijima A, Ito M, Yoshino O, Saito S.
    • Journal Title

      J Reprod Immunol.

      Volume: 108 Pages: 78-82

    • DOI

      10.1016/j.jri.2015.02.005

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Paternal antigen specific-regulatory T cells are induced by tolerogeneic DCs after seminal plasma priming2016

    • Author(s)
      Tomoko Shima, Kumiko Inada, Akemi Ushijima, Akitoshi Nakashima, Osamu Yoshino, Shigeru Saito
    • Organizer
      13th Congress of the International Society for Immunology of Reproduction and the European Society for Reproductive Immunology
    • Place of Presentation
      Erfurt、Germany
    • Year and Date
      2016-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 精漿によるプライミングによる父親抗原特異的母児免疫寛容の誘導2015

    • Author(s)
      島友子、稲田 貢三子、牛島明美、伊藤実香、中島彰俊、吉野修、齋藤滋
    • Organizer
      第67日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 精漿によるプライミングによる父親抗原特異的母児免疫寛容の誘導2015

    • Author(s)
      島友子、稲田貢三子、牛島明美、伊藤実香、中島彰俊、吉野修、齋藤滋
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 精漿によるプライミングは抑制性樹状細胞を誘導しトレランスを確立し妊娠成立に関与する2014

    • Author(s)
      島友子、稲田貢三子、中島彰俊、吉野修、齋藤滋
    • Organizer
      第66日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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