The role of seminal fuid in paternal antigen specific feto-maternal tolerance
Project/Area Number |
26861316
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | University of Toyama |
Principal Investigator |
Shima Tomoko 富山大学, 医学薬学研究部(医学), 助教 (00377285)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 精漿 / 父親抗原特異的制御性T細胞 / 免疫寛容誘導性樹状細胞 / 母児免疫寛容 / 制御性T細胞 / 制御性樹状細胞 |
Outline of Final Research Achievements |
Fetus is a semi-allograft to maternal immune system. We have shown that paternal antigen specific regulatory T cells have an active role for feto-maternal tolerance. And, it is known that antigen specific regulatory T cells are induced after antigen presentation by tolerogenic dendritic cells (DC). We analyzed the role of seminal fuid in paternal antigen specific feto-maternal tolerance with focused on paternal antigen specific Treg and tolerogenic DC. Seminal fluid priming is important for the induction of tolerogenic DC and patarnal antigen specific Treg. The crosstalk of DC and Treg is important for success of pregnancy.
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Report
(3 results)
Research Products
(5 results)