Creation of the model of multistep carcinogenesis derived from ovarian endometrioma by introducing defined genetic elements

Research Project

Project/Area Number	26861317
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Obstetrics and gynecology
Research Institution	Kanazawa University
Principal Investigator	Bono Yukiko 金沢大学, 大学病院, 助教 (80565416)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	子宮内膜症 / 卵巣がん / 癌化 / 卵巣チョコレート嚢胞の癌化
Outline of Final Research Achievements	Ｍalignant transformation of endometriotic epithelial cells required overexpression of c-myc or phospho-Akt or mutation of PIK3CA in addition to dysfunctional p53 and mutated KRAS. Since overexpresison of phospho-Akt or mutation of PIK3CA lead to activate c-Myc by its phosphorylation, c-Myc activation in ovarian endometrioma might play a key role in transformation in the presence of dysfunctional p53 and activated ERK pathway.