| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
This study aimed to clarify the pathophysiological role of APOBEC deaminases in HPV infection. We obtained the following conclusion. 1. APOBECs are induced by interferons and HPV 2. APOBECs hypermutate HPV or host genomes, and their expression correlates with integration of HPV genome into the host 3. On the contrary, APOBECs decrease infectivity of HPV virion when expressed in virion-producing cells. These finding revealed the bilateral role of APOBECs as antiviral and oncogenic molecules, in HPV infection.
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