Development of anti-metastatic therapy for hematogenous lung metastasis of uterine sarcoma
Project/Area Number |
26861319
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | University of Occupational and Environmental Health, Japan (2015-2016) University of Fukui (2014) |
Principal Investigator |
Ishikane Shin 産業医科大学, 医学部, 助教 (40470190)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
Keywords | 生理活性ペプチド / 血行性癌転移 / 子宮肉腫 / 悪性黒色腫 / 血管内皮細胞 / 抗転移薬 / 血行性肺転移 |
Outline of Final Research Achievements |
To develop effective treatments for cancer metastasis, we revealed relationship between circulating regulatory peptides and hematogenous cancer metastasis. C-type natriuretic peptide (CNP) did not reduce the growth and metastasis of uterine sarcomas, but reduced the metastasis of melanoma cells. CNP may be a useful inhibitor of the melanoma cell metastasis. Angiotensin II (Ang II) increased the expression of cell adherent molecules in the pulmonary vascular endothelial cells, and exacerbated the hematogenous cancer metastasis. Ang II induced metastasis was not prevented by Ca channel antagonist treatment, but was prevented by Ang II receptor blocker (ARB) treatment. ARB may be a useful for the prevention of cancer metastasis in cancer patients with hypertension.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Establishment and characterization of a novel orthotopic mouse model for human uterine sarcoma with different metastatic potentials.2015
Author(s)
Kawabe, S., Mizutani, T., Ishikane, S., Martines, ME., Kiyono, Y., Miura, K., Hosoda, H., Imamichi, Y., Kangawa, K., Miyamoto, K., Yoshida Y.
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Journal Title
Cancer Letters
Volume: 366
Issue: 2
Pages: 182-190
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional regulation of genes related to progesterone production [Review]2015
Author(s)
Mizutani, T., Ishikane, S., Kawabe, S., Umezawa, A., Miyamoto, K.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 9
Pages: 757-763
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex2015
Author(s)
Mizutani, T., Kawabe, S., Ishikane, S., Imamichi, Y., Umezawa, A., Miyamoto, K.
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Journal Title
Molecular and Cellular Endocrinology
Volume: 408
Pages: 133-137
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015
Author(s)
Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
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Journal Title
Proc Natl Acad Sci USA
Volume: 112
Issue: 13
Pages: 4086-4091
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice2015
Author(s)
Kimura, T., Nojiri, T., Hosoda, H., Ishikane, S., Shintani, Y., Inoue, M., Miyazato, M., Okumura, M., Kangawa, K.
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Journal Title
Journal of Surgical Research
Volume: 194
Pages: 631-637
Related Report
Peer Reviewed
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[Journal Article] Protective effects of C-type natriuretic peptide on cisplatin-induced nephrotoxicity in mice2015
Author(s)
Kimura, T., Nojiri, T., Hosoda, H., Ishikane, S., Shintani, Y., Inoue, M., Miyazato, M., Okumura, M., Kangawa, K.
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Journal Title
Cancer Chemotherapy and Pharmacology
Volume: 75(5)
Issue: 5
Pages: 1057-1063
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] C/EBPβ (CCAAT/enhancer-binding protein β ) mediates progesterone production through transcriptional regulation in co-operation with SF-1 (steroidogenic factor-1 )2014
Author(s)
Mizutani, T., Ju, Y., Imamichi, Y., Osaki, T., Yazawa, T., Kawabe, S., Ishikane, S., Matsumura, T., Kanno, M., Kamiki, Y., Kimura, K., Minamino, N., Miyamoto, K.
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Journal Title
Biochem. J.
Volume: 460
Issue: 3
Pages: 459-471
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells.2014
Author(s)
Yamahara K, Harada K, Ohshima M, Ishikane S, Ohnishi S, Tsuda H, Otani K, Taguchi A, Soma T, Ogawa H, Katsuragi S, Yoshimatsu J, Harada-Shiba M, Kangawa K, Ikeda T.
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Journal Title
PLoS One. 2014 Feb 14;9(2):e88319.
Volume: 9
Issue: 2
Pages: e88319-e88319
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury2014
Author(s)
Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Kimura T, Shintani Y, Inoue M, Sawabata N, Miyazato M, Okumura M, Kangawa K
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Journal Title
Pulm Pharmacol Ther
Volume: 29
Issue: 1
Pages: 24-30
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury2014
Author(s)
Nojiri T, Hosoda H, Kimura T, Miura K, Ishikane S, Tokudome T, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K
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Journal Title
Cancer Chemother Pharmacol
Volume: 75
Issue: 1
Pages: 123-129
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Atrial natriuretic peptide attenuates pulmonary metastasis enhanced by angiotensin II through regulation of tumor-cell adhesion to vascular endothelial cells2014
Author(s)
Ishikane, S., Mizutani, T., Hosoda, H., Tokudome, T., Nojiri, T., Kimura, T., Miura, K., Kawabe, S., Imamichi, Y., Miyazato, M., Kangawa, K., Miyamoto, K.
Organizer
The Conference on Bioactive Peptides for Cell-Cell Communication 2014
Place of Presentation
ホテルグランディア京都(京都市下京区)
Year and Date
2014-09-10 – 2014-09-12
Related Report
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[Presentation] Protective effect of C-type natriuretic peptide on lipopolysaccharide-induced acute lung injury in mice2014
Author(s)
Kimura, T., Nojiri, T., Hoshoda, H., Ishikane, S., Miyazato, M., Kangawa, K.
Organizer
The Conference on Bioactive Peptides for Cell-Cell Communication 2014
Place of Presentation
ホテルグランディア京都(京都市下京区)
Year and Date
2014-09-10 – 2014-09-12
Related Report
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[Presentation] Steroidogenic Factor 1 (SF-1) and C/EBPβ cooperatively regulate progesterone production. 16th International Congress of Endocrinology2014
Author(s)
Mizutani, T., Imamichi, Y., Kawabe, S., Ishikane, S., Osaki, T., Minamino, N., Miyamoto, K.
Organizer
The Endocrine Society's 96th Annual Meeting & EXPO 2014
Place of Presentation
McCormic Place(米国・シカゴ)
Year and Date
2014-06-21 – 2014-06-24
Related Report
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