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The therapeutic strategy for lung hypoplasia in congenital diaphragmatic hernia in a rat model

Research Project

Project/Area Number 26861322
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionNagoya University

Principal Investigator

TSUDA HIROYUKI  名古屋大学, 医学部附属病院, 講師 (40571328)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords先天性横隔膜ヘルニア / 肺高血圧 / リモデリング / 柴苓湯 / 胎児治療 / ET-1 / 肺血管リモデリング / 肺低形成
Outline of Final Research Achievements

Congenital diaphragmatic hernia (CDH) can induce lung hypoplasia and pulmonary hypertension, and is associated with high mortality. The purpose of this study is to examine the efficacy and safety of antenatal Saireito (TJ-114), a traditional Japanese herbal medicine, in a rat CDH model. Sprague-Dawley rats were exposed to an herbicide (nitrofen, 100 mg) on embryonic day 9 (E9) to induce CDH, and antenatal Saireito (2000 mg/kg/day) was orally administered from E10 to E20. On E21 fetuses were delivered. Antenatal Saireito significantly decreased the incidence of CDH (p < 0.01), and increased lung volume (p < 0.01), improved alveolarization and pulmonary artery remodeling using histological analysis, and respiratory function using gasometric analysis (pH; p < 0.05, and PCO2; p < 0.01). Taken together, our results demonstrated that antenatal Saireito can improve fetal pulmonary hypoplasia and pulmonary vascular remodeling, as a result, can improve respiratory function in a rat CDH model.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Antenatal saireito (TJ-114) can improve pulmonary hypoplasia and pulmonary vascular remodeling in nitrofen-induced congenital diaphragmatic hernia2016

    • Author(s)
      S. Hirako, H. Tsuda, T. Kotani, S. Sumigama, Y. Mano, T. Nakano, K. Imai, H. Li H, S. Toyokuni, F. Kikkawa
    • Journal Title

      Phytotherapy Research

      Volume: 30 Issue: 9 Pages: 1474-1480

    • DOI

      10.1002/ptr.5645

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 先天性横隔膜ヘルニアにおける漢方薬を用いた治療の可能性2015

    • Author(s)
      平光志麻、津田弘之、伊藤由美子、森山佳則、諸井博明、今井健史、中野知子、炭竃誠二、小谷友美、吉川史隆
    • Organizer
      第35回産婦人科漢方研究会
    • Place of Presentation
      ベルサール飯田橋駅前(東京都千代田区)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 先天性横隔膜ヘルニアに対する治療戦略2014

    • Author(s)
      平光志麻、津田弘之、牛田貴文、諸井博明、今井健史、中野知子、服部友香、渡部百合子、眞野由紀雄、炭竃誠二、小谷友美、吉川史隆
    • Organizer
      第50回日本周産期新生児学会
    • Place of Presentation
      シェラトン・グランデ・トーキョー・ベイホテル(千葉県浦安市)
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 先天性横隔膜ヘルニアに対する治療戦略 ~柴苓湯を用いた新しい胎児治療の可能性~2014

    • Author(s)
      平光志麻、津田弘之、牛田貴文、諸井博明、今井健史、中野知子、服部友香、渡部百合子、眞野由紀雄、炭竃誠二、小谷友美、吉川史隆
    • Organizer
      第66回日本産科婦人科学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-17 – 2014-04-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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