microRNA is involved in the pathogenesis of endometriosis.

Research Project

Project/Area Number	26861336
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Obstetrics and gynecology
Research Institution	Oita University
Principal Investigator	ABE WAKANA 大分大学, 医学部, 病院特任助教 (30457618)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	子宮内膜症 / エピジェネティクス / microRNA / micro RNA
Outline of Final Research Achievements	Utilizing miRNA microarray analysis, we found 8 downregulated miRNAs and 4 upregulated miRNAs in cultured ECSCs. Compulsory expression of miR-503 directed the inhibition of cell proliferation and the induction of apoptosis in ECSCs. miR-503 was found to suppress the mRNA expression of Bcl-2, VEGF-A and Cyclin D1 in ECSCs.