Pivotal roles of CX3CL1-CX3CR1 systems in ovarian cancer progression

• Project/Area Number: 26861338
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Wakayama Medical University
• Principal Investigator: Horiuchi Yuko 和歌山県立医科大学, 医学部, 博士研究員 (60596972)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 卵巣癌 / 微小環境 / ケモカイン・サイトカイン / 腹膜播種 / サイトカイン・ケモカイン

Outline of Final Research Achievements

Despite the development of cytoreductive surgery and chemotherapy, epithelial ovarian cancer has the highest case-fatality rate among gynecologic cancers. In the biology of tumor growth and metastasis, the interactions between tumor and stromal cells via chemokine systems are essential. Several previous studies demonstrated that CX3CL1-CX3CR1 system was crucial in various disease models such as ischemia-reperfusion renal injury, bacterial peritonitis and inflammatory colitis. In this study, we explored the pathophysiological roles of CX3CL1-CX3CR1 system in ovarian cancer progression.

Research Products

• [Journal Article] A Third Surgically Managed Ectopic Pregnancy after Two Salpingectomies Involving the Opposite Tube. (2017)
  • Author(s): Iwahashi N, Deguchi Y, Horiuchi Y, Ino K, Furukawa K.
  • Journal Title: Case Rep Obstet Gynecol. 2017 Volume: 2017 Pages: 1-3
  • DOI: 10.1155/2017/1653529
  • Peer Reviewed / Open Access
• [Journal Article] Identical twins with mature cystic teratomas treated with laparoscopic surgery: Two case reports. (2017)
  • Author(s): Mabuchi Y, Ota N, Kobayashi A, Tanizaki Y, Minami S, Ino K.
  • Journal Title: Mol Clin Oncol Volume: 6 Issue: 2 Pages: 276-278
  • DOI: 10.3892/mco.2016.1118
  • Peer Reviewed
• [Journal Article] Primary tumor SUV(max) on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy. (2016)
  • Author(s): Yagi S, Yahata T, Mabuchi Y, Tanizaki Y, Kobayashi A, Shiro M, Ota N, Minami S, Terada M, Ino K.
  • Journal Title: Mol Clin Oncol Volume: 5 Issue: 3 Pages: 216-222
  • DOI: 10.3892/mco.2016.953
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of primary tumor SUV(max) on preoperative (18)F-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography in endometrial cancer and uterine carcinosarcoma. (2016)
  • Author(s): Yahata T, Yagi S, Mabuchi Y, Tanizaki Y, Kobayashi A, Yamamoto M, Mizoguchi M, Nanjo S, Shiro M, Ota N, Minami S, Terada M, Ino K.
  • Journal Title: Mol Clin Oncol Volume: 5 Issue: 4 Pages: 467-474
  • DOI: 10.3892/mco.2016.980
  • Peer Reviewed / Open Access
• [Journal Article] AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer. (2015)
  • Author(s): Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T.
  • Journal Title: Eur. J. Pharmacol. Volume: 766 Pages: 63-75
  • DOI: 10.1016/j.ejphar.2015.09.039
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathologic Factors of Cervical Adenocarcinoma Stages IB to IIB (2015)
  • Author(s): Mabuchi Y, Yahata T, Kobayashi A, Tanizaki Y, Shiro M, Ota N, Yagi S, Minami S, Ino K
  • Journal Title: Int J Gynecol Cancer Volume: 25 Issue: 9 Pages: 1677-1682
  • DOI: 10.1097/igc.0000000000000542
  • Peer Reviewed
• [Journal Article] Vaginal carcinoma in a young woman who underwent fertility-sparing treatment involving (2015)
  • Author(s): Mabuchi Y, Yahata T, Kobayashi A, Tanizaki Y, Minami S, Ino K.
  • Journal Title: J Obstet Gynaecol Res. Volume: 41 Issue: 6 Pages: 989-992
  • DOI: 10.1111/jog.12638
  • Peer Reviewed
• [Journal Article] Acute fatty liver of pregnancy associated with fetal mitochondrial trifunctional protein deficiency (2015)
  • Author(s): Kobayashi T, Minami S, Mitani A, Tanizaki Y, Booka M, Okutani T, Yamaguchi S, Ino K
  • Journal Title: J Obstet Gynaecol Res Volume: 41 Issue: 5 Pages: 799-802
  • DOI: 10.1111/jog.12609
  • Peer Reviewed
• [Journal Article] Diagnostic value of preoperative SUVmax on FDG-PET/CT for the detection of ovarian cancer (2014)
  • Author(s): Tanizaki Y, Kobayashi A, Shiro M, Ota N, Takano R, Mabuchi Y, Yagi S, Minami S, Terada M, Ino K
  • Journal Title: Int J Gynecol Cancer Volume: 24(3) Issue: 3 Pages: 454-60
  • DOI: 10.1097/igc.0000000000000074
  • Peer Reviewed
• [Journal Article] Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment. (2014)
  • Author(s): Tanizaki Y(1), Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 8 Pages: 966-73
  • DOI: 10.1111/cas.12445
  • Peer Reviewed / Open Access
• [Presentation] CX3CL1-CX3CR1 system enhances ovarian cancer progression via recruitment of CX3CR1 positive tumor associated macrophages (TAMs) (2016)
  • Author(s): Yuko Tanizaki, Aya Kobayashi, Tamaki Yahata, Mika Mizoguchi, Michihisa Shiro, Nami Ota, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino
  • Organizer: 第68回 日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] Fractalkine systemが腫瘍随伴マクロファージの動員を介して卵巣癌腹膜播種を促進する (2015)
  • Author(s): 谷﨑優子，小林彩，東嶋左緒里，溝口美佳，石田裕子，野坂みずほ，木村章彦，馬淵泰士，八木重孝，南佐和子，向田直史，近藤稔和，井箟一彦
  • Organizer: 第53回 日本癌治療学会
  • Place of Presentation: 京都府
  • Year and Date: 2015-10-29
• [Presentation] フラクタルカインシステムがTAMを誘導し卵巣癌腹膜播種を促進する (2015)
  • Author(s): 谷﨑優子，小林彩，東嶋左緒里，石田裕子，野坂みずほ，木村章彦，南佐和子，向田直史，近藤稔和，井箟一彦
  • Organizer: 第57回 日本婦人科腫瘍学会
  • Place of Presentation: 岩手県
  • Year and Date: 2015-08-07
• [Presentation] 腫瘍随伴マクロファージ（TAM）および腫瘍関連線維芽細胞（CAF）の卵巣癌微小環境内動員におけるケモカインシステムの促進的役割 (2015)
  • Author(s): 谷﨑優子，小林彩，東嶋左緒里，溝口美佳，八幡環，石田裕子，野坂みずほ，木村章彦，馬淵泰士，南佐和子，向田直史，近藤稔和，井箟一彦
  • Organizer: 第14回 日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 長野県
  • Year and Date: 2015-07-17
• [Presentation] CX3CL1-CX3CRシステムは腫瘍随伴マクロファージの動員を介して卵巣癌腹膜播種を促進する (2015)
  • Author(s): 谷﨑優子，小林彩，溝口美佳，城道久，太田菜美，馬淵泰士，八木重孝，南佐和子，井箟一彦
  • Organizer: 第67回 日本産婦人科学会
  • Place of Presentation: 神奈川県
  • Year and Date: 2015-04-09
• [Presentation] CX3CL1-CX3CR1 システムは腫瘍随伴マクロファージを誘導し卵巣癌腹膜播種を促進する (2014)
  • Author(s): 谷﨑優子，小林彩 ，東嶋左緒里 ，石田裕子，野坂みずほ，木村章彦，中村靖司，南佐和子，向田直史，近藤稔和，井箟一彦
  • Organizer: ＷＡＭＴ 和歌山腫瘍研究会
  • Place of Presentation: 和歌山
  • Year and Date: 2014-12-13
• [Presentation] 卵巣癌腹膜播種におけるフラクタルカインシステムの分子病理学的役割の解明 (2014)
  • Author(s): 谷﨑優子，小林彩，東嶋左緒里，溝口美佳，八幡環，城道久，馬淵泰士，八木重孝，南佐和子，井箟一彦
  • Organizer: 第56回 日本婦人科腫瘍学会
  • Place of Presentation: 栃木
  • Year and Date: 2014-07-17 – 2014-07-19
• [Presentation] マウス卵巣癌腹膜播種モデルにおけるフラクタルカインシステムの分子病理学的役割の検討 (2014)
  • Author(s): 谷﨑優子，小林彩，東嶋左緒里，石田裕子，木村章彦，野坂みずほ，向田直史，近藤稔和，井箟一彦
  • Organizer: 第23回 がん転移学会学術集会
  • Place of Presentation: 石川
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Essential involvement of CX3CL1-CX3CR1 system in ovarian cancer progression (2014)
  • Author(s): Yuko Tanizaki, Aya Kobayashi, Saori Toujima, Yumi Kuninaka, Mizuho Nosaka, Yuko Ishida, Akihiko Kimura, Naofumi Mukaida, Kazuhiko Ino, Toshikazu Kondo
  • Organizer: 第22回 マクロファージ分子細胞生物学国際シンポジウム
  • Place of Presentation: 兵庫
  • Year and Date: 2014-06-02 – 2014-06-03
• [Presentation] 卵巣癌進展におけるCX3CL1-CX3CR1システムの分子病理学的役割の解析 (2014)
  • Author(s): 谷崎優子，小林彩，八幡環，山本円，城道久，太田菜美，馬淵泰士，八木重孝，南佐和子，井箟一彦
  • Organizer: 第66回 日本産婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-19