Pivotal roles of CX3CL1-CX3CR1 systems in ovarian cancer progression
| Project/Area Number |
26861338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Horiuchi Yuko 和歌山県立医科大学, 医学部, 博士研究員 (60596972)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 卵巣癌 / 微小環境 / ケモカイン・サイトカイン / 腹膜播種 / サイトカイン・ケモカイン |
|---|
| Outline of Final Research Achievements |
Despite the development of cytoreductive surgery and chemotherapy, epithelial ovarian cancer has the highest case-fatality rate among gynecologic cancers. In the biology of tumor growth and metastasis, the interactions between tumor and stromal cells via chemokine systems are essential. Several previous studies demonstrated that CX3CL1-CX3CR1 system was crucial in various disease models such as ischemia-reperfusion renal injury, bacterial peritonitis and inflammatory colitis. In this study, we explored the pathophysiological roles of CX3CL1-CX3CR1 system in ovarian cancer progression.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Prognostic impact of primary tumor SUV(max) on preoperative (18)F-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography in endometrial cancer and uterine carcinosarcoma.2016
Author(s)
Yahata T, Yagi S, Mabuchi Y, Tanizaki Y, Kobayashi A, Yamamoto M, Mizoguchi M, Nanjo S, Shiro M, Ota N, Minami S, Terada M, Ino K.
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Journal Title
Mol Clin Oncol
Volume: 5
Issue: 4
Pages: 467-474
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer.2015
Author(s)
Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T.
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Journal Title
Eur. J. Pharmacol.
Volume: 766
Pages: 63-75
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment.2014
Author(s)
Tanizaki Y(1), Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.
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Journal Title
Cancer Sci.
Volume: 105
Issue: 8
Pages: 966-73
DOI
Related Report
Peer Reviewed / Open Access
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