Development of the HIF-1-specific inhibitor in ovarian clear cell carcinoma
Project/Area Number |
26861343
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Tokai University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | HIF-1 / 卵巣明細胞腺癌 / HDAC7 / シリビニン / Vorinostat / HIF-1活性化阻害剤 / HDAC |
Outline of Final Research Achievements |
Histone Deacetylase (HDAC) is an enzyme deacetylating the histone which is a main constitution factor in chromatin structure and play an important role in genetic transcription control. HDAC is involved in intracellular signal transduction and the control of the cell cycle and in late years attracts attention as target molecule of the cancer therapy.In this study, focusing on HDAC7, we analyzed their immunohistochemical expression in ovarian cancer and assessed their mRNAs expression in cultured ovarian cancer cell lines. HDAC inhibitor (HDI)-induced changes in the expression of mRNAs for HDAC7, HIF-1α and VEGF were also attempted to assess the potential anti-cancer effect of HDI. As a result, it was shown that the inhibitory effect of HDI on HDAC7 and HIF-1 varies among cell lines. We suppose that the response to HDI may vary greatly among patients with ovarian cancer and that the ovarian cancer with high expression of HDAC7 may be a suitable candidate for HDI treatment.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Fully-sialylated alpha-chain of complement 4-binding protein:Diagnostic utility for ovarian clear cell carcinoma2015
Author(s)
Mikio Mikami,Kazuhiro Tanabe,Koji Matsuo,Yuko Miyazaki,Masaki Miyazawa,Masaru Hayashi,Satoshi Asai,Masae Ikeda,Masako Shida,Takeshi Hirasawa,Nozomi Kojima,Ryuichiro Sho,Sadato Iijima
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Journal Title
Gynecologic Oncology
Volume: 138(3)
Issue: 3
Pages: 520-528
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma2014
Author(s)
Goto Y, Kametani Y*, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M
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Journal Title
BioScience Trends
Volume: 8
Issue: 2
Pages: 93-100
DOI
NAID
ISSN
1881-7815, 1881-7823
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 高齢者子宮内膜癌の病理学的検討2015
Author(s)
大金直樹, 鴨志田伸吾, 宮澤昌樹, 加藤久盛, 亀田陽一, 堀慎一, 加藤智美, 安田政実
Organizer
第104回日本病理学会総会
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2015-04-30
Related Report
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[Presentation] 卵巣明細胞腺癌におけるHDAC阻害剤を通じたHIF-1活性化機構の制御2014
Author(s)
宮澤 昌樹, 宮澤 麻里子, 加藤 智美, 藤井 幸子, 松井 成明, 平澤 猛, 信田 政子, 池田 仁惠, 浅井 哲, 村松 俊成, 梶原 博, 安田 政実, 三上 幹男
Organizer
第55回日本組織細胞化学会総会・学術集会
Place of Presentation
松本市中央公民館
Year and Date
2014-09-27 – 2014-09-28
Related Report
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[Presentation] 子宮頸部腺癌においてSulfatideは高発現している(Enhanced Expression of Sulfatide, a Sulfated Glycolipid, In Uterine Cervical Adenocarcinomas)2014
Author(s)
宮澤 昌樹, 杉山 太朗, 宮澤 麻里子, 藤井 幸子, 池田 仁惠, 信田 政子, 平澤 猛, 村松 俊成, 松井 成明, 梶原 博, 岩森 正男, 三上 幹男
Organizer
第73回日本癌学会学術総会
Place of Presentation
パシフィコ横浜
Year and Date
2014-09-25 – 2014-09-27
Related Report
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[Presentation] 子宮頸癌におけるSulfatideの発現とその機能について2014
Author(s)
宮澤 昌樹, 宮澤 麻里子, 松井 成明, 藤井 幸子, 杉山 太朗, 西島 義博, 池田 仁惠, 信田 政子, 平澤 猛, 梶原 博, 村松 俊成, 岩森 正男, 三上 幹男
Organizer
第56回日本婦人科腫瘍学会学術講演会
Place of Presentation
栃木県総合文化センター
Year and Date
2014-07-17 – 2014-07-19
Related Report
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[Presentation] 明細胞腺癌におけるHDAC familyによるHIF-1活性化機序の解明2014
Author(s)
平澤 猛, 宮澤 昌樹, 宮澤 麻里子, 天津 慎子, 楢山 知紗, 柏木 寛史, 浅井 哲, 池田 仁惠, 信田 政子, 安田 政実, 三上 幹男
Organizer
第56回日本婦人科腫瘍学会学術講演会
Place of Presentation
栃木県総合文化センター
Year and Date
2014-07-17 – 2014-07-19
Related Report
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[Presentation] 卵巣明細胞腺癌188例の臨床病理学的検討2014
Author(s)
鈴木 裕之, 安田 政実, 吉田 正行, 宮澤 昌樹, 岡垣 竜吾, 石原 理, 藤原 恵一
Organizer
第66回日本産科婦人科学会学術講演会
Place of Presentation
東京国際フォーラム
Year and Date
2014-04-18 – 2014-04-20
Related Report