Mechanism of follicle development using CNP on aging mice
| Project/Area Number |
26861346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
YORINO SATO 聖マリアンナ医科大学, 医学部, 研究技術員 (00511073)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 卵胞発育 / aging / CNP / 加齢マウス / 加齢 / 生殖医学 |
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| Outline of Final Research Achievements |
Follicle growth is necessary follicle stimulate hormone. However FSH low responder or aging woman patients resist follicle growth by FSH stimulation. We found CNP induce follicle development acting through cGMP increasing under FSH. In this study, we identified candidate of CNP downstream and clarified molecular mechanism of follicle development. Furthermore, we evaluated oocyte quality of aging model mice.
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Report
(4 results)
Research Products
(3 results)
