Analysis of mitochondrial DNA in head and neck cancer

• Project/Area Number: 26861353
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: Mizumachi Takatsugu 北海道大学, 大学病院, 助教 (00507577)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 頭頸部癌 / 中咽頭癌 / HPV / ミトコンドリアDNA / 耳鼻咽喉科 / 頭頚部腫瘍 / 喉頭癌 / 喉頭乳頭腫 / 頭頸部腫瘍

Outline of Final Research Achievements

The 8th edition AJCC/UICC TNM staging is effective for HPV-related oropharyngeal squamous cell carcinoma (OPSCC) after January 1,2017. We retrospectively analyzed 175 patients with OPSCC treated in Hokkaido University Hospital between 1998 and 2014. Of the 152 OPSCC patients, 83 (47.4%) were positive for HPV, and 92 (52.6%) were negative. 3-year overall survival rate was significantly lower in the HPV-negative patients with stage III and IV as compared with stage I and II. 3-year overall survival rate was not significantly different between stage I-III versus stage IV . According to 8th edition AJCC/UICC TNM staging system, 3-year overall survival rate was relatively distinguishable between stage I-II and III. The 7th edition AJCC/UICC TNM staging system is acceptable for HPV-negative patients, however, unsuitable for HPV-positive patients. The 8th edition AJCC/UICC TNM staging system is suitable for HPV-related OPSCC in Japan.

Research Products

• [Journal Article] Confirmation of the eighth edition of the AJCC/UICC TNM staging system for HPV-mediated oropharyngeal cancer in Japan. (2017)
  • Author(s): Mizumachi T, Homma A, Sakashita T, Kano S, Hatakeyama H, Fukuda S.
  • Journal Title: Int J Clin Oncol. Volume: 印刷中 Issue: 4 Pages: 682-689
  • DOI: 10.1007/s10147-017-1107-0
  • NAID: 120006491498
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MRI and 18F-FDG PET/CT of Laryngeal Cartilaginous Tumor. (2017)
  • Author(s): Nakagawa J, Manabe O, Mizumachi T, Kanno-Okada H, Hatanaka KC, Mitsuhashi T, Oyama-Manabe N, Hirata K, Tamaki N.
  • Journal Title: Clin Nucl Med. Volume: 42 Issue: 3 Pages: e157-e160
  • DOI: 10.1097/rlu.0000000000001493
  • Peer Reviewed
• [Journal Article] Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. (2017)
  • Author(s): Kano S, Homma A, Hatakeyama H, Mizumachi T, Sakashita T, Kakizaki T, Fukuda S.
  • Journal Title: Head Neck. Volume: 39 Issue: 2 Pages: 247-253
  • DOI: 10.1002/hed.24576
  • NAID: 120006382285
  • Peer Reviewed
• [Journal Article] A retrospective study of G-tube use in Japanese patients treated with concurrent chemoradiotherapy for hypopharyngeal cancer. (2016)
  • Author(s): Homma A, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Kuramoto R, Nakamaru Y, Onimaru R, Tsuchiya K, Yoshida D, Yasuda K, Shirato H, Fukuda S.
  • Journal Title: Plos One Volume: 11 Issue: 8 Pages: e0161734-e0161734
  • DOI: 10.1371/journal.pone.0161734
  • NAID: 120005866840
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of prophylactic neck dissection and tumor thickness evaluation for patients with cN0 tongue squamous cell carcinoma. (2016)
  • Author(s): Tsushima N, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Kakizaki T, Suzuki T, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 273 Pages: 3987-3992
  • NAID: 120006360053
  • Peer Reviewed
• [Journal Article] Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis. (2016)
  • Author(s): Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 273 Issue: 10 Pages: 3331-3336
  • DOI: 10.1007/s00405-016-3933-5
  • NAID: 120006347189
  • Peer Reviewed
• [Journal Article] Early and long-term morbidity after minimally invasive total laryngo-pharyngo-esophagectomy with gastric pull-up reconstruction via thoracoscopy, laparoscopy and cervical incision. (2015)
  • Author(s): Homma A, Nakamaru Y, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Shichinohe T, Ebihara Y, Hirano S, Furukawa H, Hayashi T, Yamamoto Y, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 272 Issue: 11 Pages: 3551-3556
  • DOI: 10.1007/s00405-014-3420-9
  • NAID: 120005853057
  • Peer Reviewed
• [Journal Article] Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience. (2015)
  • Author(s): Homma A, Nakamaru Y, Sakashita T, Onimaru R, Terasaka S, Tsuchiya K, Yoshida D, Yasuda K, Hatakeyama H, Furusawa J, Mizumachi T, Kano S, Shirato H, Fukuda S.
  • Journal Title: Auris Nasus Larynx Volume: 42 Issue: 5 Pages: 377-381
  • DOI: 10.1016/j.anl.2015.02.005
  • NAID: 120005906880
  • Peer Reviewed
• [Journal Article] Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer. (2015)
  • Author(s): Sakashita T, Homma A, Hatakeyama H, Furusawa J, Kano S, Mizumachi T, Iizuka S, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S.
  • Journal Title: Int J Clin Oncol. Volume: 20 Issue: 6 Pages: 1081-1085
  • DOI: 10.1007/s10147-015-0821-8
  • NAID: 120005890011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of acute toxicities associated with cetuximab-based bioradiotherapy and platinum-based chemoradiotherapy for head and neck squamous cell carcinomas: A single-institution retrospective study in Japan. (2015)
  • Author(s): Sakashita T, Homma A, Hatakeyama H, Furusawa J, Kano S, Mizumachi T, Iizuka S, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S.
  • Journal Title: Acta Otolaryngologica Volume: 135 Issue: 8 Pages: 853-858
  • DOI: 10.3109/00016489.2015.1030772
  • NAID: 120005820705
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck. (2015)
  • Author(s): Homma A, Sakashita T, Hatakeyama H, Kano S, Mizumachi T, Nakamaru Y, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S.
  • Journal Title: Acta Otolaryngol. Volume: 135 Issue: 9 Pages: 950-954
  • DOI: 10.3109/00016489.2015.1040171
  • NAID: 120005828501
  • Peer Reviewed
• [Journal Article] ヒト乳頭腫ウイルス（HPV）関連中咽頭癌 (2015)
  • Author(s): 折舘伸彦、水町貴諭、佐野大祐
  • Journal Title: 耳鼻咽喉科展望 Volume: 58 Pages: 194-197
  • NAID: 130005169734
  • Peer Reviewed
• [Journal Article] Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma. (2014)
  • Author(s): Mizumachi T, Homma A, Kakizaki T, Sakashita T, Kano S, Hatakeyama H, Tsuchiya K, Yasuda K, Onimaru R, Shirato H, Taguchi J, Shimizu Y, Kinoshita I, Akita H, Fukuda S.
  • Journal Title: Int J Clin Oncol. Volume: Ｅｐuｂ
  • NAID: 120005906778
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synchronous HPV-Positive Squamous Cell Carcinoma of the Bilateral Base of the Tongue (2014)
  • Author(s): Mizumachi T, Sakashita T, Hoshimura Y, Kakizaki T, Homma A, Mitsuhashi T, Fukuda S.
  • Journal Title: Otolaryngology Volume: 4 Issue: 02
  • DOI: 10.4172/2161-119x.1000164
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation. (2014)
  • Author(s): Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 271 Issue: 10 Pages: 2767-2770
  • DOI: 10.1007/s00405-013-2806-4
  • NAID: 120005665822
  • Peer Reviewed / Open Access
• [Journal Article] Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy. (2014)
  • Author(s): Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S.
  • Journal Title: Br J Oral Maxillofac Surg Volume: 52 Issue: 4 Pages: 323-328
  • DOI: 10.1016/j.bjoms.2014.01.018
  • NAID: 120005476154
  • Peer Reviewed / Open Access
• [Journal Article] Epithelial-mesenchymal transition in human papillomavirus;positive and -negative oropharyngeal squamous cell carcinoma (2014)
  • Author(s): Hiromitsu Hatakeyama, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma, Satoshi Fukuda
  • Journal Title: Oncology Report Volume: 9 Issue: 6 Pages: 2673-2679
  • DOI: 10.3892/or.2014.3509
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The potential diagnostic role of the number of ultrasonographic characteristics for patients with thyroid nodules evaluated as bethesdaI-v. (2014)
  • Author(s): Sakashita T, Homma A, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Iizuka S, Hoshino K, Hatanaka KC, Oba K, Fukuda S.
  • Journal Title: Front Oncol. Volume: 4 Pages: 261-261
  • DOI: 10.3389/fonc.2014.00261
  • Peer Reviewed / Open Access
• [Journal Article] Radiological images of keratocystoma: a rare tumor of the parotid gland. (2014)
  • Author(s): Hirata K, Fujima N, Mizumachi T, Bandarchi B, Roesler JM.
  • Journal Title: Acta Radiol Short Rep. Volume: Ｅｐuｂ Issue: 8
  • DOI: 10.1177/2047981614549497
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Early and long-term morbidity after minimally invasive total laryngo-pharyngo-esophagectomy with gastric pull-up reconstruction via thoracoscopy, laparoscopy and cervical incision. (2014)
  • Author(s): Homma A, Nakamaru Y, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Shichinohe T, Ebihara Y, Hirano S, Furukawa H, Hayashi T, Yamamoto Y, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol Volume: Ｅｐuｂ
  • NAID: 120005853057
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 頸部腫瘤摘出・生検後に中咽頭癌と診断された症例の検討 (2014)
  • Author(s): 水町 貴諭 加納 里志, 坂下 智博, 畠山 博充, 本間 明宏, 福田 諭
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 117 Pages: 1463-1470
  • NAID: 130004913865
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 原発不明頸部リンパ節転移におけるヒト乳頭腫ウイルスの解析 (2014)
  • Author(s): 加納 里志, 本間 明宏, 鈴木 清護, 畠山 博充, 古沢 純, 水町 貴諭, 坂下 智博, 折舘 伸彦, 福田 諭
  • Journal Title: 頭頸部癌 Volume: 40 Pages: 344-348
  • NAID: 130004706092
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 頭頸部扁平上皮癌とHPV (2014)
  • Author(s): 水町 貴諭, 折舘 伸彦
  • Journal Title: JOHNS Volume: 30 Pages: 1619-1621
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 初診時メラノーシスと診断され2年以上経過したあとに悪性黒色腫と診断された1例 (2014)
  • Author(s): 木村 将吾, 水町 貴諭, 干野 季美子, 本間 明宏, 福田 諭
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 86 Pages: 931-935
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 中咽頭扁平上皮癌症例に対するWeekly CDDP併用化学放射線療法の臨床的検討 (2014)
  • Author(s): 水町 貴諭, 本間 明宏, 坂下 智博, 加納 里志, 畠山 博充, 土屋 和彦, 安田 耕一, 鬼丸 力也, 白土 博樹, 福田 諭
  • Journal Title: 頭頸部癌 Volume: 40 Pages: 66-70
  • NAID: 130004940773
  • Peer Reviewed
• [Journal Article] 癌予測に有用なエコー所見に関する検討 術前細胞診で癌が確定しなかった症例を対象に (2014)
  • Author(s): 坂下 智博, 本間 明宏, 畠山 博充, 水町 貴諭, 加納 里志, 古沢 純, 飯塚 さとし, 畑中 佳奈子, 福田 諭
  • Journal Title: 日本内分泌・甲状腺外科学会雑誌 Volume: 31 Pages: 130-133
  • NAID: 130004682711
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] HPV 関連中咽頭癌症例におけるTNM 分類改訂にともなう病期分類と生存率の検討 (2016)
  • Author(s): 水町貴諭、本間明宏、坂下智博、加納里志、畠山博充、福田諭
  • Organizer: 第214 回日本耳鼻咽喉科学北海道地方部会
  • Place of Presentation: 札幌医科大学（北海道札幌市）
  • Year and Date: 2016-10-30
• [Presentation] シンポジウム２ 頭頸部癌におけるHPV関連癌とその治療戦略 (2016)
  • Author(s): 水町貴諭
  • Organizer: 第1 回日本HPV 研究会・学術集会
  • Place of Presentation: TKP横浜駅西口カンファレンスセンター（神奈川県横浜市）
  • Year and Date: 2016-10-19
• [Presentation] Human papillomavirus and survival of the patients with oropharyngeal cancer in Hokkaido, Japan (2016)
  • Author(s): Mizumachi T, Homma A, Sakashita T, Kano S, Hatakeyama H, Fukuda S
  • Organizer: 9th International Conference on Head and Neck Cancer
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-07-16
  • Int'l Joint Research
• [Presentation] 中咽頭扁平上皮癌に対する化学放射線療法施行症例の臨床的検討 (2016)
  • Author(s): 水町貴諭、坂下智博、加納里志、畠山博充、本間明宏、土屋 和彦、安田 耕一、鬼丸 力也、白土 博樹、福田諭
  • Organizer: 第40 回日本頭頸部癌学会
  • Place of Presentation: ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2016-06-09
• [Presentation] 喉頭乳頭腫症例におけるHPV感染と治療成績の検討 (2016)
  • Author(s): 水町 貴諭 溝口 兼司 畠山 博充
  • Organizer: 第28回日本喉頭科学会
  • Place of Presentation: コングレコンベンションセンター（大阪府大阪市）
  • Year and Date: 2016-03-03
• [Presentation] 喉頭腫瘍におけるHPV 感染の検討 (2015)
  • Author(s): 水町貴諭、中薗彬、坂下智博、加納里志、畠山博充、本間明宏、福田諭
  • Organizer: 第67 回日本気管食道科学会
  • Place of Presentation: ザ・セレクトン福島（福島県福島市）
  • Year and Date: 2015-11-19
• [Presentation] Human papillomavirus and survival of patients with oropharyngeal cancer in Hokkaido, Japan (2015)
  • Author(s): Mizumachi T, Kano S, Sakashita T, Hatakeyama H, Homma A, Fukuda S
  • Organizer: 4th Congress of Asian Society of Head and Neck Oncology
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] 喉頭癌T1症例の臨床的検討 (2015)
  • Author(s): 水町貴諭、中薗彬、坂下智博、加納里志、畠山博充、本間明宏、福田諭
  • Organizer: 第116回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-05-20
• [Presentation] Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma. (2014)
  • Author(s): Mizumachi T, Homma A, Kakizaki T, Sakashita T, Kano S, Hatakeyama H, Tsuchiya K, Yasuda K, Onimaru R, Shirato H, Taguchi J, Shimizu Y, Kinoshita I, Akita H, Fukuda S.
  • Organizer: 5th WORLD CONGRESS of International Fiederation of Head and Neck Oncologic Societies (IFHNOS)
  • Place of Presentation: Marriott Marquis Time Square(New York, USA)
  • Year and Date: 2014-07-26 – 2014-07-30
• [Presentation] 局所進行頭頸部癌に対する導入化学療法後のweekly CDDP併用化学放射線療法の安全性と有用性の検討 (2014)
  • Author(s): 水町貴諭、本間明宏、坂下智博、加納里志、畠山博充、清水康、秋田弘俊、土屋和彦、安田耕一、鬼丸 力也、白土博樹、福田諭
  • Organizer: 第38回日本頭頸部癌学会
  • Place of Presentation: 東京ファッションタウンビル（東京都）
  • Year and Date: 2014-06-12 – 2014-06-13