Investigation of the pathophysiology of postviral olfactory disorder and its application to treatment

Research Project

Project/Area Number	26861358
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	The University of Tokyo
Principal Investigator	Kanaya Kaori 東京大学, 医学部附属病院, 臨床登録医 (90456129)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	嗅粘膜 / マクロファージ / 嗅上皮
Outline of Final Research Achievements	The pathogenesis of postviral olfactory disorder(PVOD) has not been clarified. In this study, we focused on the secondary damage of olfactory neuroepithelium caused by host immune responses and the regeneration of olfactory neuroepithelium after the tissue damage caused by methimazole. Intranasal administration of TLR7 ligands didn't induce the inflammatory cells infiltration and the olfactory neuroepithelial damage. In macrophage depletion model mice, the olfactory neuroepithelial regeneration was incomplete.It was suggested that macrophages were deeply involved in the regeneration of the olfactory neuroepithelium.

Report

(4 results)