Analysis of gene expression and function of TRP receptor in nasal polyps of eosinophilic chronic rhinosinusitis
| Project/Area Number |
26861360
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIEDA Shigeharu 福井大学, 医学部, 教授 (30238539)
NOGUCHI Emiko 筑波大学, 医学医療系, 教授 (40344882)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 好酸球性副鼻腔炎 / 鼻茸 / TRPV3 / 次世代シーケンサー / トランスクリプトーム |
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| Outline of Final Research Achievements |
The number of patients with eosinophilic chronic rhinosinusitis (ECRS) tends to be increased in recent years in Japan. Whole transcriptome analysis with next generation sequencer (RNA-seq) was conducted to investigate molecular biological mechanism of ECRS. RNA-seq showed that 3 genes were significantly highly expressed in nasal polyps of ECRS. In these genes, TRPV3 (transient receptor potential cation channel, subfamily V, member 3) was the only gene which is not expressed in peripheral blood eosinophils.
Further study showed that TRPV3 was highly expressed in infiltrating eosinophils and mucosal epithelium of nasal polyps of ECRS. This results suggested that TRPV3 may play a role of refractoriness of ECRS.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study2015
Author(s)
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
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Journal Title
Allergy.
Volume: Epub ahead of print
Pages: 995-1003
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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