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Analysis of gene expression and function of TRP receptor in nasal polyps of eosinophilic chronic rhinosinusitis

Research Project

Project/Area Number 26861360
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

Tokunaga Takahiro  福井大学, 医学部附属病院, 特命助教 (10464075)

Co-Investigator(Renkei-kenkyūsha) FUJIEDA Shigeharu  福井大学, 医学部, 教授 (30238539)
NOGUCHI Emiko  筑波大学, 医学医療系, 教授 (40344882)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords好酸球性副鼻腔炎 / 鼻茸 / TRPV3 / 次世代シーケンサー / トランスクリプトーム
Outline of Final Research Achievements

The number of patients with eosinophilic chronic rhinosinusitis (ECRS) tends to be increased in recent years in Japan. Whole transcriptome analysis with next generation sequencer (RNA-seq) was conducted to investigate molecular biological mechanism of ECRS. RNA-seq showed that 3 genes were significantly highly expressed in nasal polyps of ECRS. In these genes, TRPV3 (transient receptor potential cation channel, subfamily V, member 3) was the only gene which is not expressed in peripheral blood eosinophils.
Further study showed that TRPV3 was highly expressed in infiltrating eosinophils and mucosal epithelium of nasal polyps of ECRS. This results suggested that TRPV3 may play a role of refractoriness of ECRS.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 好酸球性副鼻腔炎の診断と治療2016

    • Author(s)
      徳永 貴広, 藤枝 重治
    • Journal Title

      週刊日本医事新報

      Volume: 4800 Pages: 36-41

    • NAID

      130003395285

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study.2015

    • Author(s)
      Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
    • Journal Title

      Allergy

      Volume: Epub ahead of print Issue: 8 Pages: 995-1003

    • DOI

      10.1111/all.12644

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 好酸球性副鼻腔炎 診断ガイドライン (JESREC Study)2015

    • Author(s)
      藤枝 重治, 坂下 雅文, 徳永 貴広, 岡野 光博, 春名 威範, 他
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 118 Pages: 728-735

    • NAID

      130005088297

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.2015

    • Author(s)
      Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, Tahara-Hanaoka S, Shibuya A.
    • Journal Title

      PLoS One, 10(12), 2015

      Volume: 10 Issue: 12 Pages: 1-16

    • DOI

      10.1371/journal.pone.0144436

    • NAID

      120007130029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 好酸球性副鼻腔炎の診断基準2015

    • Author(s)
      徳永貴広、坂下雅文、二之宮貴裕、意元義政、冨田かおり、森川太洋、藤枝重治
    • Journal Title

      アレルギー・免疫

      Volume: 22 Pages: 22-28

    • Related Report
      2014 Research-status Report
  • [Presentation] Whole transcriptome解析(RNA-Seq)により同定された好酸球性副鼻腔炎関連遺伝子2016

    • Author(s)
      徳永 貴広, 意元 義政, 坂下 雅文, 高林 哲司, 藤枝 重治
    • Organizer
      第34回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      鳥羽国際ホテル
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Novel scoring system and algorithm for classifying eosinophilic chronic rhinosinusitis: The JESREC Study2015

    • Author(s)
      T.Tokunaga, M.Sakashita, T.Ninomiya, Y.Imoto, T.Morikawa, K.Tomita, T.Takabayashi, S.Fujieda & JESREC group
    • Organizer
      The 9th Biennal Symposium of International Eosinophil Society
    • Place of Presentation
      Holiday Inn Mart Plaza
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次世代シーケンサーを用いたWhole transcriptome解析(RNA-seq)による好酸球性副鼻腔炎関連遺伝子の同定2015

    • Author(s)
      徳永 貴広, 二之宮 貴裕, 意元 義政, 坂下 雅文, 野口 恵美子, 藤枝 重治
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪国際館パミール
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いたWhole transcriptome解析(RNA-seq)による好酸球性副鼻腔炎関連遺伝子の同定2015

    • Author(s)
      徳永貴広、二之宮貴裕、意元義政、坂下雅文、野口恵美子、藤枝重治
    • Organizer
      第64回日本アレルギー学会
    • Place of Presentation
      東京都・品川・グランドプリンスホテル新高輪 国際館パミール
    • Year and Date
      2015-05-26 – 2015-05-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 次世代シーケンサーを用いたWhole transcriptome解析(RNA-seq)による好酸球性副鼻腔炎関連遺伝子の同定2015

    • Author(s)
      徳永貴広、意元義政、坂下雅文、藤枝重治
    • Organizer
      第33回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東京都・錦糸町・東武ホテルレバント東京
    • Year and Date
      2015-02-26 – 2015-02-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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