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Replication study of candidate genes associated with Age-Related Hearing Impairment in the Japanese population

Research Project

Project/Area Number 26861366
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionShinshu University

Principal Investigator

SUZUKI Nobuyoshi  信州大学, 医学部附属病院, 医員 (20377641)

Co-Investigator(Renkei-kenkyūsha) USAMI Shin-ichi  信州大学, 学術研究院医学系, 教授 (10184996)
NISHIO Shin-ya  信州大学, 学術研究院医学系, 助教 (70467166)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords遺伝子 / 老人性難聴 / SNP / 候補遺伝子関連解析 / SNPs
Outline of Final Research Achievements

Age-related hearing impairment (ARHI) or presbycusis is the most common sensory neural impairment in the elderly. Several genes have been reported as susceptibility genes for ARHI in the European population: GRHL2, NAT2, GRM7 and IQGAP2, and in the Japanese population: MTHFR and MTR. We tried to replicate previously reported associated SNPs in Age related hearing loss. We tried to replicate previously reported associated SNPs in 620 samples from a Japanese population, aged 50-75 years. None of the previously found SNPs showed significant associations with ARHI in our Japanese population. Until now, all previous association results remain un-replicated. ARHI is a highly complex disorder, involving many variants with small effect sizes, which require larger studies with more power.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] 補聴器適合検査の指針(2010)における検査結果の変化2014

    • Author(s)
      鈴木伸嘉、宇佐美真一
    • Organizer
      聴覚医学会
    • Place of Presentation
      海峡メッセ下関・下関市・山口県
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 長野県における軽度・中等度難聴児補聴器購入助成事業の現状2014

    • Author(s)
      鈴木伸嘉、宇佐美真一
    • Organizer
      小児耳鼻咽喉科学会
    • Place of Presentation
      アクトシティ浜松・浜松市・静岡県
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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