Replication study of candidate genes associated with Age-Related Hearing Impairment in the Japanese population
| Project/Area Number |
26861366
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
USAMI Shin-ichi 信州大学, 学術研究院医学系, 教授 (10184996)
NISHIO Shin-ya 信州大学, 学術研究院医学系, 助教 (70467166)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 遺伝子 / 老人性難聴 / SNP / 候補遺伝子関連解析 / SNPs |
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| Outline of Final Research Achievements |
Age-related hearing impairment (ARHI) or presbycusis is the most common sensory neural impairment in the elderly. Several genes have been reported as susceptibility genes for ARHI in the European population: GRHL2, NAT2, GRM7 and IQGAP2, and in the Japanese population: MTHFR and MTR. We tried to replicate previously reported associated SNPs in Age related hearing loss. We tried to replicate previously reported associated SNPs in 620 samples from a Japanese population, aged 50-75 years. None of the previously found SNPs showed significant associations with ARHI in our Japanese population. Until now, all previous association results remain un-replicated. ARHI is a highly complex disorder, involving many variants with small effect sizes, which require larger studies with more power.
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Report
(4 results)
Research Products
(2 results)
