Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
H19 is an imprinted gene and has maternal monoallelic expression. H19 was first described as a tumor suppressor, but more recent studies show that H19 expression is reactivated in human cancer. However, the role and biological significance of H19 in esophageal cancer and head and neck cancer remain unexplored. We have reported that: Increase of H19 in NEFH-deficient cells. H19 knockdown in NEFH-deficient cells decreased the cell growth. H19 may function as an oncogene in NEFH-loss mediated esophageal cancer and head and neck cancer.
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