Establishment of a method for early detection of head and neck cancer by evaluation of H19 gene.

• Project/Area Number: 26861368
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Okamura Jun 浜松医科大学, 医学部, 助教 (00402305)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 頭頸部癌 / H19 / NEFH / バイオマーカー / miR-675 / Biomarker / 頭頚部癌 / h19

Outline of Final Research Achievements

H19 is an imprinted gene and has maternal monoallelic expression. H19 was first described as a tumor suppressor, but more recent studies show that H19 expression is reactivated in human cancer. However, the role and biological significance of H19 in esophageal cancer and head and neck cancer remain unexplored. We have reported that: Increase of H19 in NEFH-deficient cells. H19 knockdown in NEFH-deficient cells decreased the cell growth. H19 may function as an oncogene in NEFH-loss mediated esophageal cancer and head and neck cancer.