| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The purpose of this study was to establish new therapeutic methods for inflammatory substances in olfactory disorders. First, we analyzed data obtained by the whole-cell patch-clamp method using living human olfactory cells. As a result, we have reported many new olfactory cell findings. Subsequently, we confirmed the reactions caused by inflammatory substance administration. Inflammation control was also examined and its effects on traumatic olfactory disorder in mice.
As a result, preliminary results on human olfactory cells were obtained, but the influence of inflammatory substances could not be confirmed. This is probably because human olfactory cells are extremely fragile compared to other animal species. However, this study discovered multiple effective substances in traumatic olfactory-impaired mice, which are expected to be applied clinically in the future.
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