The establishment of therapeutic methods for olfactory disorders with a focus on inflammation
Project/Area Number |
26861370
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
|
Research Institution | Mie University |
Principal Investigator |
Tamari Kengo 三重大学, 教養教育機構, 特任講師(教育担当) (90585176)
|
Research Collaborator |
KOBAYASHI Masayoshi
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 電気生理学 / 嗅覚 / 炎症 / 嗅粘膜 / 嗅細胞 / 炎症物質 / 免疫組織化学染色 / EP2受容体 / 嗅覚機能検査 |
Outline of Final Research Achievements |
The purpose of this study was to establish new therapeutic methods for inflammatory substances in olfactory disorders. First, we analyzed data obtained by the whole-cell patch-clamp method using living human olfactory cells. As a result, we have reported many new olfactory cell findings. Subsequently, we confirmed the reactions caused by inflammatory substance administration. Inflammation control was also examined and its effects on traumatic olfactory disorder in mice. As a result, preliminary results on human olfactory cells were obtained, but the influence of inflammatory substances could not be confirmed. This is probably because human olfactory cells are extremely fragile compared to other animal species. However, this study discovered multiple effective substances in traumatic olfactory-impaired mice, which are expected to be applied clinically in the future.
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Report
(5 results)
Research Products
(2 results)