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Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis

Research Project

Project/Area Number 26861371
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionShiga University of Medical Science

Principal Investigator

Tojima Ichiro  滋賀医科大学, 医学部, 助教 (80567347)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords好酸球性副鼻腔炎 / 鼻茸 / ILC2 / IL-33 / アレルギー性鼻炎 / 喘息 / IL-5 / IL-13 / 好酸球 / 気管支喘息 / IL-25
Outline of Final Research Achievements

ILC2s represent a critical innate cellular source of type 2 cytokines and may play important roles in various diseases. We examined the role of ILC2s in the pathogenesis of two subgroups of CRSwNP; ECRS and non-ECRS. We analyzed the prevalence of ILC2s in sinonasal tissues and in blood from patients with ECRS, non-ECRS, CRSsNP and control. The prevalence of ILC2s in nasal tissues was higher in patients with ECRS as compared to those with non-ECRS or CRSsNP. The prevalence of blood ILC2s was not different between patients with ECRS and non-ECRS. The prevalence of blood ILC2s was higher in patients with allergic rhinitis and elevated serum IgE levels. Alternaria-induced IL-33 secretion was increased in nasal epithelial cells derived from patients with ECRS as compared to those from patients with non-ECRS or CRSsNP. ILC2s may be involved in the pathogenesis of CRSwNP, in particular in patients with tissue eosinophilia (i.e. ECRS).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis2016

    • Author(s)
      Ichiro Tojima, Hideaki Kouzaki, Shino Shimizu, Takao Ogawa, Masahiko Arikata, Hirohito Kita, Takeshi Shimizu
    • Journal Title

      Clinical Immunology

      Volume: 170 Pages: 1-8

    • NAID

      130005628327

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 好酸球性副鼻腔炎におけるグループ2自然リンパ球(ILC2)の役割2017

    • Author(s)
      戸嶋一郎
    • Organizer
      第36回気道分泌研究会
    • Place of Presentation
      東京グランドホテル(東京都港区)
    • Year and Date
      2017-04-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Group 2 Innate Lymphoid Cells Are Increased in Nasal Polyps in Patients with Eosinophilic Chronic Rhinosinusitis2017

    • Author(s)
      Ichiro Tojima
    • Organizer
      2017 AAAAI Annual Meeting Atlanta
    • Place of Presentation
      Atlanta (USA)
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Group 2 innate lymphoid cells (ILC2s) are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis2016

    • Author(s)
      Ichiro Tojima
    • Organizer
      第55回日本鼻科学会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of group 2 innate lymphoid cells in the pathogenesis of eosinophilic chronic rhinosinusitis2016

    • Author(s)
      Ichiro Tojima
    • Organizer
      26th Congress of the European Rhinologic Society
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2016-07-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Role of group 2 innate lymphoid cells (ILC2s) and IL-33 in the pathogenesis of eosinophilic chronic rhinosinusitis2015

    • Author(s)
      Ichiro Tojima
    • Organizer
      Rhinology Research Forum in Asia (RReFA) Annual Meeting 2015
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Group 2 innate lymphoid cells:IL-33の産生と好酸球浸潤・増殖の関連2015

    • Author(s)
      戸嶋一郎
    • Organizer
      第54回日本鼻科学会総会・学術講演会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 好酸球性副鼻腔炎におけるILC22015

    • Author(s)
      戸嶋一郎
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Presentation] 鼻副鼻腔疾患における好酸球とILC22015

    • Author(s)
      戸嶋一郎
    • Organizer
      第33回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東武ホテルレバント東京
    • Year and Date
      2015-02-26 – 2015-02-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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