The molecular biological research of a new treatment of viral-induced inner ear dysfunction

Research Project

Project/Area Number	26861374
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Osaka University
Principal Investigator	Takimoto Yasumitsu 大阪大学, 医学(系)研究科(研究院), 特任研究員 (00624298)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	内耳障害 / 末梢前庭機能 / TLR3 / 内耳炎 / 内耳 / 前庭機能
Outline of Final Research Achievements	We revaeled TLR3mRNA expression in the mouse cochlea, spiral ganglion, and vestibular ganglion using RT-PCR and in situ hybridization. After poly I:C intratympanic administration, the infiltration of inflammatory cells was observed in the treatment side of inner ear. We developed new evaluation system of mouse vestibular function.