Prognostic value of ALDH polymorphism in Japanese patients with oropharyngeal cancer
| Project/Area Number |
26861379
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | 中咽頭癌 / ALDH / アルコール / 遺伝子多型 / 予後因子 / HPV / 重複癌 / 頭頸部癌 / ADH |
|---|
| Outline of Final Research Achievements |
As a prognostic factor in oropharyngeal cancer, HPV and smoking have been mentioned in European and American studies and well recognized. However, in Japan, there were some reports reporting the influence of alcohol on oropharyngeal cancer in the past. It was assumed that the Japanese are attributed to the fact that ALDH heterozygos which is responsible for alcohol metabolism in particular are many. We searched gene polymorphisms in 81 patients with oropharyngeal carcinoma and examined them. As a result, it was suggested that genetic polymorphism of ALDH may be affected by prognosis rather than smoking and HPV status.
|
Report
(4 results)
Research Products
(4 results)
