| Project/Area Number |
26861383
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tottori University |
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Principal Investigator |
Yazama Hiroaki 鳥取大学, 医学部附属病院, 助教 (30444631)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 頭頸部癌 / 抗腫瘍効果 / セラミド / 血管新生 / 食餌性グルコシルセラミド / 血管新生増殖因子 |
|---|
| Outline of Final Research Achievements |
We found that dietary glucosylceramides isolated from rice bran (Glu-Cer), known as a health food, had anti-tumor activity in HNSCC xenograft model, and extended mouse survival time in comparison with vehicle control. Then, we found that oral administration of Glu-Cer inhibited angioinvasion and significantly decreased SCCKN growth in the xenograft model. In tumor-invated areas, VEGF and HIF-1α in tumor cells, as well as VEGF receptor-2 in endothelial cells decreased after treatment. Dietary Glu-Cer increased serum levels of sphingosine-based ceramides compared to the control. In SCCKN and UV♀2 cells, C6-ceramide suppressed the expressions of pro-angiogenic signals in vitro. These results might suggest that sphingosine-based ceramide suppresses the growth of head and neck tumors due to the inhibition of pro-angiogenic signals.
And we have already started to examine some mechanisms about tumor invasion and metastasis.
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