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Elucidation of the body's factors affecting shear wave velocity in thyroid

Research Project

Project/Area Number 26861385
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionTottori University

Principal Investigator

Fukuhara Takahiro  鳥取大学, 医学部附属病院, 助教 (80403418)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords超音波 / shear wave / 頭頸部癌 / 甲状腺 / エラストグラフィ / ARFI / shear wave elastography / 音響放射圧 / elastography / 甲状腺癌
Outline of Final Research Achievements

First, we verified the utility of shear wave elastography as an adjunct to differentiating thyroid nodules or diagnosing chronic autoimmune thyroiditis. Secondly, we clarified that the shear wave velocity (SWV) becomes fast in the fibrotic tissue in thyroid, so the shear wave velocity is fast in the malignant thyroid tissue that occurs sever fibrosis. Thirdly, we elucidated the artifacts in the measurement of SWV in thyroid region by comparing the SWV in vivo with that assessed in resected specimens. The measurement of SWV was negligibly affected by physical factors such as carotid artery pulsation or respiratory movements. The measurement of SWV was not rendered unstable by either heterogeneous pathology or the refraction or reflection of shear waves at the rounded surfaces of nodules. Heterogeneous pathology may attenuate shear waves.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (34 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (29 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results)

  • [Journal Article] Correlation Between Quantitative Shear Wave Elastography and Pathologic Structures of Thyroid2015

    • Author(s)
      Takahiro Fukuhara, Eriko Matsuda, Yukari Endo, Masao Takenobu, Shoichiro Izawa, Kazunori Fujiwara, Hiroya Kitano
    • Journal Title

      Ultrasound in Medicine and Biology

      Volume: 41 Issue: 9 Pages: 2326-2332

    • DOI

      10.1016/j.ultrasmedbio.2015.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Utility of Shear Wave Elastography for Diagnosing Chronic Autoimmune Thyroiditis2015

    • Author(s)
      Takahiro Fukuhara, Eriko Matsuda, Shoichiro Izawa, Kazunori Fujiwara, Hiroya Kitano
    • Journal Title

      Journal of Thyroid Research

      Volume: なし

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of fibrotic rissue on shear wave velocity in thyroid: an ex vivo study with fresh thyroid specimens2015

    • Author(s)
      Takahiro fukuhara, Eriko Matsuda, Yukari Endo, Ryohei Donishi, Soichiro Izawa, Kazunori Fujiwara, Hiroya Kitano, Hiromi Takeuchi
    • Journal Title

      BioMed Research International

      Volume: なし

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phantom experiment and clinical utility of quantitative shear wave elastography for differentiating thyroid nodules.2014

    • Author(s)
      Fukuhara T, Matsuda E, Fujiwara K, Tanimura C, Izawa S, Kataoka H, Kitano H
    • Journal Title

      Endocrine Journal

      Volume: 61 Pages: 615-621

    • NAID

      130004770459

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 診断と経過観察に超音波が有用であったCarotidyniaの1例2014

    • Author(s)
      福原隆宏、松田枝里子、北野博也
    • Journal Title

      乳腺甲状線超音波医学

      Volume: 3 Pages: 8-12

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Utility of novel elastography using acoustic radiation force impulse for diagnosing metastatic lymph node of head and neck squamous cell carcinoma –preliminary study2016

    • Author(s)
      Takahiro Fukuhara, Eriko Matsuda, Kazunori Fujiwara, Hiroya Kitano, Hiromi Takeuchi
    • Organizer
      American Head and Neck Society 9th International Conference on Head and Neck cancer
    • Place of Presentation
      Seattle (USA)
    • Year and Date
      2016-07-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 音響放射圧によるエラストグラフィーの頭頸部癌リンパ節転移診断への有用性2016

    • Author(s)
      福原隆宏、堂西亮平、松田枝里子、北野博也、竹内裕美
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 頭頸部領域の超音波検査2016

    • Author(s)
      福原隆宏
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Verification of artifacts in the measurement of shear wave velocity in the thyroid2016

    • Author(s)
      Takahiro Fukuhara, Eriko Matsuda, Hiroya Kitano, Hiromi Takeuchi
    • Organizer
      The 12th Congress of the Asian Federation of societies for Ultrasound in Medicine and Biology
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 頭頸部領域での超音波検査の活用法~頸部リンパ節診断におけるARFIエラストグラフィーの有用性~2016

    • Author(s)
      福原隆宏、北野博也、竹内裕美
    • Organizer
      第36回日本乳腺甲状線超音波医学会学術集会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 頭頸部癌の超音波診療「頭頸部領域での超音波エラストグラフィの活用法2016

    • Author(s)
      福原隆宏
    • Organizer
      平成27年度がんプロフェッショナル養成基盤推進プラン講演
    • Place of Presentation
      岩手医科大学(岩手県盛岡市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 甲状腺組織に対するshear wave特性とshear wave elastographyの臨床的有用性2016

    • Author(s)
      福原隆宏、松田枝里子、遠藤由香利、藤原和典、三宅成智、北野博也、竹内裕美
    • Organizer
      第44回中国四国甲状腺外科研究会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impact of fibrotic tissue on shear wave velocity in thyroid: an ex vivo study with fresh thyroid specimens2015

    • Author(s)
      Takahiro Fukuhara, Hiroya Kitano
    • Organizer
      1st Congress of Asia-Pacific Society of Thyroid Surgery
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The utility of shear wave elastography using acoustic radiation force impulse in diagnosing chronic autoimmune thyroiditis2015

    • Author(s)
      Takahiro Fukuhara, Eriko Matsuda, Kazunori Fujiwara, Satoshi Koyama, Hiroya Kitano
    • Organizer
      1st Congress of Asia-Pacific Society of Thyroid Surgery
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Virtual Touch Imaging (VTI) による甲状腺結節の良悪性診断2015

    • Author(s)
      福原隆宏、松田枝里子、横山裕子、藤井太平、北野博也、竹内裕美
    • Organizer
      第35回日本乳腺甲状線超音波医学会学術集会
    • Place of Presentation
      いわて県民情報交流センター「アイーナ」(岩手県盛岡市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 超音波検査による多型腺腫とワルチン腫瘍の鑑別の検討2015

    • Author(s)
      松田枝里子、福原隆宏、北野博也、竹内裕美
    • Organizer
      第35回日本乳腺甲状線超音波医学会学術集会
    • Place of Presentation
      いわて県民情報交流センター「アイーナ」(岩手県盛岡市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] The utility of shear wave elastography using acoustic radiation force impulse in diagnosing chronic autoimmune thyroiditis2015

    • Author(s)
      Fukuhara T, Matsuda E, Fujiwara K, Koyama S, Kitano H
    • Organizer
      Congress of Asia-Pacific Society of Thyroid Surgery
    • Place of Presentation
      Seoul(Korea)
    • Year and Date
      2015-06-25 – 2015-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 甲状腺結節良悪性診断における音響放射圧を利用したエラストグラフィの有用性2015

    • Author(s)
      福原隆宏、松田枝里子、北野博也
    • Organizer
      第34回乳腺甲状線超音波医学会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都)
    • Year and Date
      2015-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸部に適したShear Wave Elastographyの測定方向の検討2015

    • Author(s)
      松田枝里子、福原隆宏、北野博也
    • Organizer
      第34回乳腺甲状線超音波医学会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都)
    • Year and Date
      2015-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭頸部領域の摘出標本を用いたsheaar wave速度に関与する病理組織像の解明2015

    • Author(s)
      福原隆宏、松田枝里子、堂西亮平、北野博也
    • Organizer
      日本超音波医学会第88回学術集会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都港区)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性甲状腺炎におけるQuantitative shear wave elastographyの有用性2015

    • Author(s)
      松田枝里子、福原隆宏、堂西亮平、北野博也
    • Organizer
      日本超音波医学会第88回学術集会
    • Place of Presentation
      グランドプリンスホテル高輪 (東京都港区)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 甲状腺結節良悪性診断における音響放射圧を利用したエラストグラフィの有用性2015

    • Author(s)
      福原隆宏、松田枝里子、北野博也
    • Organizer
      第34回日本乳腺甲状線超音波医学会学術集会
    • Place of Presentation
      グランドプリンスホテル高輪 (東京都港区)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頸部に適したShear Wave Elastographyの測定方向の検討2015

    • Author(s)
      松田枝里子、福原隆宏、北野博也
    • Organizer
      第34回日本乳腺甲状線超音波医学会学術集会
    • Place of Presentation
      グランドプリンスホテル高輪 (東京都港区)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頭頸部領域の摘出標本を用いたsheaar wave速度に関与する病理組織像の解明2015

    • Author(s)
      福原隆宏、松田枝里子、堂西亮平、北野博也
    • Organizer
      第88回日本超音波医学会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都)
    • Year and Date
      2015-05-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 慢性甲状腺炎におけるQuantitative shear wave elastographyの有用性2015

    • Author(s)
      松田枝里子、福原隆宏、堂西亮平、北野博也
    • Organizer
      第88回日本超音波医学会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都)
    • Year and Date
      2015-05-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Correlation between histopathology and shear wave elastography findings in fresh thyroid specimens2015

    • Author(s)
      Fukuhara T, Matsuda E, Yendo Y, Fujiwara K, Kataoka H, Kitano H
    • Organizer
      American Head and Neck Society Annual Meeting
    • Place of Presentation
      Boston(USA)
    • Year and Date
      2015-04-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Correlation between histopathology and shear wave elastography findings in fresh thyroid specimens2015

    • Author(s)
      Takahiro Fukuhara, Eriko Matsuda, Yukari Endo, Kazunori Fujiwara, Hideyuki Kataoka, Hiroya Kitano
    • Organizer
      American Head and Neck Society Annual Meeting
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-04-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 音響放射圧(ARFI)によって発生したShear waveの組織内伝達速度を決定する組織像の解明2014

    • Author(s)
      福原隆宏、藤原和典、山崎愛語、竹内英二、北野博也
    • Organizer
      第47回日本甲状腺外科学会
    • Place of Presentation
      アクトス福岡(福岡市)
    • Year and Date
      2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Virtual Touch Imagingにて食道憩室が鮮明に描出された1例2014

    • Author(s)
      福原隆宏、松田枝里子、堂西亮平、北野博也
    • Organizer
      第33回乳腺甲状線超音波医学会
    • Place of Presentation
      別府国際コンベンションセンター(別府市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 甲状腺疾患におけるShear wave elastographyの特性と有用性2014

    • Author(s)
      福原隆宏
    • Organizer
      第14回第大山頸部腫瘍カンファレンス
    • Place of Presentation
      全日空ホテル(米子市)
    • Year and Date
      2014-08-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Correlation between quantitative shear wave elastography and pathological structures of thyroid lesions2014

    • Author(s)
      Fukuhara T, Matsuda E, Fujiwara K, Kataoka H, Kitano H
    • Organizer
      American Head and Neck Society Annual Meeting/World Congress of International Federation of Head and Neck Oncologic Societies joint Meeting
    • Place of Presentation
      New York(USA)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 模擬臓器内で測定した頭頸部摘出検体のshear wave速度と病理組織像の比較2014

    • Author(s)
      福原隆宏、藤原和典、山崎愛語、竹内英二、北野博也
    • Organizer
      第38回日本頭頸部癌学会
    • Place of Presentation
      東京ファッションタウンビル(東京都)
    • Year and Date
      2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 甲状腺癌摘出標本のshear wave速度と病理組織像の比較2014

    • Author(s)
      福原隆宏、松田枝里子、北野博也
    • Organizer
      第32回乳腺甲状線超音波医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 耳鼻咽喉科・頭頸部外科臨床における超音波診断の有用性について2014

    • Author(s)
      福原隆宏、松田枝里子、北野博也
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-05-09
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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