| Project/Area Number |
26861386
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shimane University |
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Principal Investigator |
Noriaki Aoi 島根大学, 医学部, 准教授 (80452556)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー性鼻炎 / Toll様受容体 / アレルギー性鼻炎の制御 |
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| Outline of Final Research Achievements |
Low dose LPS or high dose LPS was intranasaly administrated together with antigen in effector phase of murine allergic rhinitis model. Low dose LPS aggravated allergic response via Th2 cytokine productions from local mast cells and cervical node lymphocytes. Although high dose LPS inhibited allergic response via general response, such as reduction of antigen-specific Th1 and Th2 cytokine production from spleen T cells, and reduction of antigen specific IgE. According to hygene-hypothesis, even after sensitization was established, high dose LPS may reduce allergic response via general renponse.Pam3CYS, the ligand of TLR2, aggravated allergic response with neutrophilic inflammation at minimum dose.
It is suggested high dose LPS may reduce allergic rhinitis after sensitization, and may be one of the treatment tools to regulate allergic rhinitis.
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