Liposome-Encapsulated Hemoglobin Alleviates Hearing Loss After Transient Cochlear Ischemia

• Project/Area Number: 26861388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Ehime University
• Principal Investigator: Okada Masahiro 愛媛大学, 医学部附属病院, 講師 (20512130)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 人工酸素運搬体 / 内耳一過性虚血 / 聴性脳幹反応 / 蝸牛有毛細胞 / 一過性内耳虚血 / 有毛細胞

Outline of Final Research Achievements

Pre-treatment or post-treatment with liposome-encapsulated hemoglobin, which is one of artificial red blood cells, was protective in mitigating hearing loss and underlying pathological damage.