Contribution of LOXL2 in lymph node metastasis of head and neck squamous cell carcinoma

Research Project

Project/Area Number	26861389
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Ehime University
Principal Investigator	Kaminota Teppei 愛媛大学, 医学部附属病院, 医員 (30611941)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	頭頸部扁平上皮癌 / 転移 / LOXL2 / エクソソーム
Outline of Final Research Achievements	To determine the participation of LOXL2 in lymph node metastasis, stable LOXL2 knockdown cells (LOXL2 KD) were established by using lentivirul vector system. LOXL2 KD cells exhibited significantly low metastatic ability the control cells in the mouse lymph node metastasis model, suggesting that LOXL2 can participate in lymph node metastasis of SCCs. Exosomes was purified from the blood of the head and neck squamous cell cancer cases. The presence of LOXL2 was confirmed by immunoblotting analyses. LOXL2 expression was high in cancer cases

Report

(3 results)